Evidence map›Paper›PMID 33293682›Full record

ArticlePediatric research2021

Concentrations of fat-soluble nutrients and blood inflammatory compounds in mother-infant dyads at birth.

Melissa K Thoene, Matthew C Van Ormer, Elizabeth R Lyden, Maranda K Thompson, Ana G Yuil-Valdes, Sathish Kumar Natarajan, Maheswari S Mukherjee, Tara M Nordgren, Jeremy D Furtado, Ann L Anderson-Berry and 2 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Melissa K ThoeneDepartment of Pediatrics, University of Nebraska Medical Center, Omaha, NE, 68198, USA. melissak.thoene@unmc.edu.
Matthew C Van OrmerDepartment of Pediatrics, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Elizabeth R LydenCollege of Public Health, University of Nebraska Medical Center, 984375 Nebraska Medical Center, Omaha, NE, 68198-4375, USA.
Maranda K ThompsonDepartment of Pediatrics, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Ana G Yuil-ValdesDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Sathish Kumar NatarajanDepartment of Nutrition & Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, 68583, UK.
Maheswari S MukherjeeCytotechnology Education, College of Allied Health Professions, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Tara M NordgrenDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, USA.
Jeremy D FurtadoDepartment of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA, 02215, USA.
Ann L Anderson-BerryDepartment of Pediatrics, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Corrine K HansonMedical Nutrition Education, College of Allied Health Professions, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Jessica N SnowdenPediatric Infectious Disease, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
University of Nebraska Medical Center · USHarvard University · USNebraska Medical Center · USUniversity of Arkansas for Medical Sciences · USUniversity of California, Riverside · USUniversity of Nebraska–Lincoln · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPerinatal inflammation adversely affects health. Therefore, aims of this IRB-approved study are: (1) compare inflammatory compounds within and between maternal and umbilical cord blood samples at the time of delivery, (2) assess relationships between inflammatory compounds in maternal and cord blood with birth characteristics/outcomes, and (3) assess relationships between blood and placental fat-soluble nutrients with blood levels of individual inflammatory compounds.

methodsMother-infant dyads were enrolled (n = 152) for collection of birth data and biological samples of maternal blood, umbilical cord blood, and placental tissue. Nutrient levels included: lutein + zeaxanthin; lycopene; α-, β-carotene; β-cryptoxanthin; retinol; α-, γ-, δ-tocopherol. Inflammatory compounds included: tumor necrosis factor-α, superoxide dismutase, interleukins (IL) 1β, 2, 6, 8, 10.

resultsMedian inflammatory compound levels were 1.2-2.3 times higher in cord vs. maternal blood, except IL2 (1.3 times lower). Multiple significant correlations existed between maternal vs. infant inflammatory compounds (range of r = 0.22-0.48). While relationships existed with blood nutrient levels, the most significant were identified in placenta where all nutrients (except δ-tocopherol) exhibited relationships with inflammatory compounds. Relationships between anti-inflammatory nutrients and proinflammatory compounds were primarily inverse.

conclusionInflammation is strongly correlated between mother-infant dyads. Fat-soluble nutrients have relationships with inflammatory compounds, suggesting nutrition is a modifiable factor. IMPACT: Mother and newborn inflammation status are strongly interrelated. Levels of fat-soluble nutrients in blood, but especially placenta, are associated with blood levels of proinflammatory and anti-inflammatory compounds in both mother and newborn infant. As fat-soluble nutrient levels are associated with blood inflammatory compounds, nutrition is a modifiable factor to modulate inflammation and improve perinatal outcomes.

Indexed as

BiomarkersCross-Sectional StudiesFemaleFetal BloodHumansInfant, NewbornInfant Nutritional Physiological PhenomenaInflammation MediatorsLipidsMaleMaternal Nutritional Physiological PhenomenaNutrientsNutritional StatusParturitionPlacentaPregnancyBiomarkersInflammation MediatorsLipidsNutrients

Identifiers

PMID33293682
OpenAlexW3111417124

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.