Evidence map›Paper›PMID 33293652›Full record

ArticleCommunications biology2020

Complimentary action of structured and unstructured domains of epsin supports clathrin-mediated endocytosis at high tension.

Jophin G Joseph, Carlos Osorio, Vivian Yee, Ashutosh Agrawal, Allen P Liu

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Cellular mechanotransduction of human osteoblasts in microgravity.bioRxiv : the preprint server for biology · 2024
    Article
  5. Article
  6. Biomechanics-mediated endocytosis in atherosclerosis.Frontiers in cardiovascular medicine · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Load adaptation by endocytic actin networks.Molecular biology of the cell · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. CALM supports clathrin-coated vesicle completion upon membrane tension increase.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jophin G JosephDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-0128-831X
Carlos OsorioDepartment of Mechanical Engineering, University of Houston, Houston, TX, USA.
Vivian YeeDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-4777-3436
Ashutosh AgrawalDepartment of Mechanical Engineering, University of Houston, Houston, TX, USA.
Allen P LiuDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA. allenliu@umich.edu.ORCID 0000-0002-0309-7018
University of Michigan · USUniversity of Houston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Membrane tension plays an inhibitory role in clathrin-mediated endocytosis (CME) by impeding the transition of flat plasma membrane to hemispherical clathrin-coated structures (CCSs). Membrane tension also impedes the transition of hemispherical domes to omega-shaped CCSs. However, CME is not completely halted in cells under high tension conditions. Here we find that epsin, a membrane bending protein which inserts its N-terminus H

Indexed as

Adaptor Proteins, Vesicular TransportCell LineCell MembraneClathrinEndocytosisFibronectinsGene Expression RegulationGene Knockdown TechniquesGreen Fluorescent ProteinsHumansLentivirusModels, MolecularMolecular Dynamics SimulationMutationProtein ConformationProtein DomainsAdaptor Proteins, Vesicular TransportClathrinenhanced green fluorescent proteinepsinFibronectinsGreen Fluorescent Proteins

Identifiers

PMID33293652
PMCPMC7722716
OpenAlexW3112522817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.