Evidence map›Paper›PMID 33293645›Full record

ArticleScientific reports2020

Clinical, metabolic, and molecular genetic characterization of hereditary methemoglobinemia caused by cytochrome b

J A Jaffey, N S Reading, O Abdulmalik, R Kreisler, G Bullock, A Wiest, N A Villani, T Mhlanga-Mutangadura, G S Johnson, L A Cohn and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

J A JaffeyDepartment of Specialty Medicine, College of Veterinary Medicine, Midwestern University, Glendale, AZ, USA. jjaffe@midwestern.edu.
N S ReadingInstitute for Clinical and Experimental Pathology, ARUP Laboratories, Salt Lake City, UT, USA.
O AbdulmalikDivision of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
R KreislerDepartment of Pathology and Population Medicine, College of Veterinary Medicine, Midwestern University, Glendale, AZ, USA.
G BullockDepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA.
A WiestSection of Medical Genetics (PennGen), School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
N A VillaniDepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA.
T Mhlanga-MutangaduraDepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA.
G S JohnsonDepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA.
L A CohnDepartment of Veterinary Medicine and Surgery, Veterinary Health Center, University of Missouri, Columbia, MO, USA.
N IsazaDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
J W HarveyDepartment of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
U GigerSection of Medical Genetics (PennGen), School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Missouri College · USMidwestern University · USUniversity of Florida · USUniversity of Pennsylvania · USARUP Laboratories (United States) · USChildren's Hospital of Philadelphia · US

Funding

Referral Ctr-Animal models of human genetic diseaseP40OD010939 · OD · UNIVERSITY OF PENNSYLVANIA · PI CASAL, MARGRET L · 2012 to 2023
$7.9M
Hemoglobin Modifiers for Sickle Cell Disease TherapyR01MD009124 · NIMHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAFO, MARTIN K · 2014 to 2018
$2.1M
NIH HHS MD009124NIH HHS OD010939NIH HHS P40 OD010939NIMHD NIH HHS R01 MD009124
6 · The paper itself

Abstract

Genotype-phenotype correlations of humans and dogs with hereditary methemoglobinemia are not yet well characterized. We determined total hemoglobin and methemoglobin (MetHb) concentrations, cytochrome b

Indexed as

Mutation, MissenseAmino Acid SubstitutionAnimalsCytochrome-B(5) ReductaseDogsFemaleGenetic Predisposition to DiseaseHemoglobinsMaleMethemoglobinMethemoglobinemiaProspective StudiesCytochrome-B(5) ReductaseHemoglobinsMethemoglobin

Identifiers

PMID33293645
PMCPMC7723051
OpenAlexW3110764396

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.