Evidence map›Paper›PMID 33293615›Full record

ArticleScientific reports2020

AnOxPePred: using deep learning for the prediction of antioxidative properties of peptides.

Tobias Hegelund Olsen, Betül Yesiltas, Frederikke Isa Marin, Margarita Pertseva, Pedro J García-Moreno, Simon Gregersen, Michael Toft Overgaard, Charlotte Jacobsen, Ole Lund, Egon Bech Hansen and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed.

  1. Article
  2. Article
  3. Effects of DietaryAnimals : an open access journal from MDPI · 2026
    Article
  4. Article
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  6. Article
  7. Article
  8. Article
  9. Marine Peptides fromNutrients · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Discovery of Iron-Chelating Peptides fromFoods (Basel, Switzerland) · 2026
    Article
  17. Review
  18. Article
  19. Antioxidant potential and genomic adaptation ofFrontiers in microbiology · 2026
    Article
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tobias Hegelund OlsenDepartment of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0000-0002-6348-4650
Betül YesiltasNational Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark.
Frederikke Isa MarinDepartment of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.
Margarita PertsevaDepartment of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.
Pedro J García-MorenoNational Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark.
Simon GregersenDepartment of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark.ORCID 0000-0001-9349-3235
Michael Toft OvergaardDepartment of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark.ORCID 0000-0002-1423-2481
Charlotte JacobsenNational Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0000-0003-3540-9669
Ole LundNational Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0000-0003-1108-0491
Egon Bech HansenNational Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0000-0002-3795-6706
Paolo MarcatiliDepartment of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark. pamar@dtu.dk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary antioxidants are an important preservative in food and have been suggested to help in disease prevention. With consumer demands for less synthetic and safer additives in food products, the food industry is searching for antioxidants that can be marketed as natural. Peptides derived from natural proteins show promise, as they are generally regarded as safe and potentially contain other beneficial bioactivities. Antioxidative peptides are usually obtained by testing various peptides derived from hydrolysis of proteins by a selection of proteases. This slow and cumbersome trial-and-error approach to identify antioxidative peptides has increased interest in developing computational approaches for prediction of antioxidant activity and thereby reduce laboratory work. A few antioxidant predictors exist, however, no tool predicting the antioxidative properties of peptides is, to the best of our knowledge, currently available as a web-server. We here present the AnOxPePred tool and web-server ( http://services.bioinformatics.dtu.dk/service.php?AnOxPePred-1.0 ) that uses deep learning to predict the antioxidant properties of peptides. Our model was trained on a curated dataset consisting of experimentally-tested antioxidant and non-antioxidant peptides. For a variety of metrics our method displays a prediction performance better than a k-NN sequence identity-based approach. Furthermore, the developed tool will be a good benchmark for future predictors of antioxidant peptides.

Indexed as

Deep LearningAmino Acid SequenceAntioxidantsFood PreservativesHumansPeptidesSoftwareAntioxidantsFood PreservativesPeptides

Identifiers

PMID33293615
PMCPMC7722737

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.