Evidence map›Paper›PMID 33293576›Full record

ArticleScientific reports2020

Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome.

Johanna P van Geffen, Frauke Swieringa, Kim van Kuijk, Bibian M E Tullemans, Fiorella A Solari, Bing Peng, Kenneth J Clemetson, Richard W Farndale, Ludwig J Dubois, Albert Sickmann and 6 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Atherogenic apolipoprotein C-III may not be as bad as we thought.Journal of thrombosis and haemostasis : JTH · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Hypolipidemic and Antithrombotic Effect of 6'-Molecules (Basel, Switzerland) · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Characteristics of cerebral ischemic stroke based on moyamoya disease and atherosclerosis-associated intracranial arterial stenosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 6 countries.

Johanna P van GeffenDepartment of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
Frauke SwieringaDepartment of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
Kim van KuijkDepartment of Pathology, CARIM, Maastricht University, Maastricht, The Netherlands.
Bibian M E TullemansDepartment of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
Fiorella A SolariLeibniz Institut für Analytische Wissenschaften - ISAS- e.V, Dortmund, Germany.
Bing PengLeibniz Institut für Analytische Wissenschaften - ISAS- e.V, Dortmund, Germany.
Kenneth J ClemetsonDepartment of Haematology, Inselspital, University of Bern, Bern, Switzerland.
Richard W FarndaleDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
Ludwig J DuboisThe M-Lab, Department of Precision Medicine, School for Oncology and Developmental Biology (GROW), Maastricht University, Maastricht, The Netherlands.
Albert SickmannLeibniz Institut für Analytische Wissenschaften - ISAS- e.V, Dortmund, Germany.
René P ZahediLeibniz Institut für Analytische Wissenschaften - ISAS- e.V, Dortmund, Germany.
Robert AhrendsLeibniz Institut für Analytische Wissenschaften - ISAS- e.V, Dortmund, Germany.
Erik A L BiessenDepartment of Pathology, CARIM, Maastricht University, Maastricht, The Netherlands.
Judith C SluimerDepartment of Pathology, CARIM, Maastricht University, Maastricht, The Netherlands.
Johan W M HeemskerkDepartment of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
Marijke J E KuijpersDepartment of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. Marijke.Kuijpers@maastrichtuniversity.nl.
Maastricht University · NLLeibniz Institute for Analytical Sciences - ISAS · DEJewish General Hospital · CAUniversity Hospital of Bern · CHUniversity of Cambridge · GBUniversity of Edinburgh · GBUniversity of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperlipidemia is a well-established risk factor for cardiovascular diseases. Millions of people worldwide display mildly elevated levels of plasma lipids and cholesterol linked to diet and life-style. While the prothrombotic risk of severe hyperlipidemia has been established, the effects of moderate hyperlipidemia are less clear. Here, we studied platelet activation and arterial thrombus formation in Apoe

Indexed as

AnimalsApolipoproteins EBlood PlateletsCholesterolDisease Models, AnimalFemaleGene Knockout TechniquesHyperlipidemiasLipidomicsMaleMicePlatelet ActivationProteomicsReceptors, LDLThrombosisApoe protein, mouseApolipoproteins ECholesterolReceptors, LDL

Identifiers

PMID33293576
PMCPMC7722935
OpenAlexW3112803729

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.