ArticleTranslational psychiatry2020
Schizophrenia polygenic risk predicts general cognitive deficit but not cognitive decline in healthy older adults.
Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Polygenic risk for schizophrenia is associated with psychomotor vigilance performance impairment during sleep deprivation in women.Translational psychiatry · 2026Article
- Polygenic scores for executive functioning as predictors of performance improvements after repeated testing in major psychiatric disorders.Scientific reports · 2026Article
- Polygenic risk for schizophrenia predicting test-measured and self-reported cognitive performance in individuals without psychosis.BMC psychiatry · 2026Article
- Differences in Performance in the Trail Making Test Part B Between Adoptees With High and Low Genetic Risk for Schizophrenia Spectrum Disorders: The Finnish Adoptive Family Study of Schizophrenia.The European journal of neuroscience · 2025Article
- Education as a Modifier of Genetic Influence on Cognitive Ability in Older Adults.Behavior genetics · 2025Article
- Genomic findings in schizophrenia and their implications.Molecular psychiatry · 2023Review
- Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment.Molecular psychiatry · 2023Review
- Environmental Enrichment Protects against Neurotoxic Effects of Lipopolysaccharide: A Comprehensive Overview.International journal of molecular sciences · 2023Review
- First-Episode Psychosis Patients Who Deteriorated in the Premorbid Period Do Not Have Higher Polygenic Risk Scores Than Others: A Cluster Analysis of EU-GEI Data.Schizophrenia bulletin · 2023Article
- Age-dependent patterns of schizophrenia genetic risk affect cognition.Schizophrenia research · 2022Article
- Clinical, Brain, and Multilevel Clustering in Early Psychosis and Affective Stages.JAMA psychiatry · 2022Article
- Article
- Interplay between polygenic propensity for ageing-related traits and the consumption of fruits and vegetables on future dementia diagnosis.BMC psychiatry · 2022Article
- Article
- Sex-specific effects of polygenic risk for schizophrenia on lifespan cognitive functioning in healthy individuals.Translational psychiatry · 2021Article
- Polygenic Risk Scores Differentiating Schizophrenia From Bipolar Disorder Are Associated With Premorbid Intelligence in Schizophrenia Patients and Healthy Subjects.The international journal of neuropsychopharmacology · 2021Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
There has been a long argument over whether schizophrenia is a neurodegenerative disorder associated with progressive cognitive impairment. Given high heritability of schizophrenia, ascertaning if genetic susceptibility to schizophrenia is also associated with cognitive decline in healthy people would support the view that schizophrenia leads to an accelerated cognitive decline. Using the population representative sample of 6817 adults aged >50 years from the English Longitudinal Study of Ageing, we investigated associations between the biennial rate of decline in cognitive ability and the schizophrenia polygenic score (SZ-PGS) during the 10-year follow-up period. SZ-PGS was calculated based on summary statistics from the Schizophrenia Working Group of the Psychiatric Genomics Consortium. Cognition was measured sequentially across four time points using verbal memory and semantic fluency tests. The average baseline verbal memory was 10.4 (SD = 3.4) and semantic fluency was 20.7 (SD = 6.3). One standard deviation (1-SD) increase in SZ-PGS was associated with lower baseline semantic fluency (β = -0.25, 95%CI = -0.40 to -0.10, p = 0.002); this association was significant in men (β = -0.36, 95%CI = -0.59 to -0.12, p = 0.003) and in those who were aged 60-69 years old (β = -0.32, 95%CI = -0.58 to -0.05, p = 0.019). Similarly, 1-SD increase in SZ-PGS was associated with lower verbal memory score at baseline in men only (β = -0.12, 95%CI = -0.23 to -0.01, p = 0.040). However, SZ-PGS was not associated with a greater rate of decline in these cognitive domains during the 10-year follow-up. Our findings highlight that while genetic susceptibility to schizophrenia conveys developmental cognitive deficit, it is not associated with an ongoing cognitive decline, at least in later life. These results do not support the neo-Kraepelinian notion of schizophrenia as a genetically determined progressively deteriorating brain disease.
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