Evidence map›Paper›PMID 33293474›Full record

ArticleAging2020

MITF functions as a tumor suppressor in non-small cell lung cancer beyond the canonically oncogenic role.

Yi-Jing Hsiao, Wen-Hsin Chang, Hsuan-Yu Chen, Yin-Chen Hsu, Su-Chin Chiu, Ching-Cheng Chiang, Gee-Chen Chang, Yi-Ju Chen, Chia-Yu Wang, Yan-Ming Chen and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Yi-Jing HsiaoDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Wen-Hsin ChangInstitute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Hsuan-Yu ChenInstitute of Statistical Science, Academia Sinica, Taipei, Taiwan.
Yin-Chen HsuDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Su-Chin ChiuInservice Master Program in Life Sciences, College of Life Sciences, National Chung-Hsing University, Taichung, Taiwan.
Ching-Cheng ChiangDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Gee-Chen ChangDivision of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Yi-Ju ChenInstitute of Chemistry, Academia Sinica, Taipei, Taiwan.
Chia-Yu WangDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Yan-Ming ChenDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chien-Yu LinInstitute of Statistical Science, Academia Sinica, Taipei, Taiwan.
Yu-Ju ChenInstitute of Chemistry, Academia Sinica, Taipei, Taiwan.
Pan-Chyr YangInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Jeremy J W ChenInstitute of Biomedical Sciences, National Chung-Hsing University, Taichung, Taiwan.
Sung-Liang YuDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
National Taiwan University · TWInstitute of Chemistry, Academia Sinica · TWInstitute of Statistical Science, Academia Sinica · TWNational Chung Hsing University · TWInstitute of Biomedical Sciences, Academia Sinica · TWNational Taiwan University Hospital · TWTaichung Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microphthalamia-associated transcription factor (MITF) is a critical mediator in melanocyte differentiation and exerts oncogenic functions in melanoma progression. However, the role of MITF in non-small cell lung cancer (NSCLC) is still unknown. We found that

Indexed as

Adenocarcinoma of LungAgedAlcohol OxidoreductasesAnimalsAnnexin A1CarcinogenesisCarcinoma, Non-Small-Cell LungCell Line, TumorCell MovementExome SequencingFemaleFrizzled ReceptorsGene Knockdown TechniquesGenes, Tumor SuppressorHumansLung NeoplasmsAlcohol OxidoreductasesAnnexin A1ANXA1 protein, humanFrizzled ReceptorsFZD7 protein, humanleukotriene B4 12-hydroxydehydrogenaseMicrophthalmia-Associated Transcription FactorMITF protein, humanFZD7metastasistranscriptome profilingWNT pathway

Identifiers

PMID33293474
PMCPMC7835003
OpenAlexW3108213196

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.