ArticleProceedings of the National Academy of Sciences of the United States of America2020
Guanine, a high-capacity and rapid-turnover nitrogen reserve in microalgal cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 80 citations in OpenAlex.
- Biosynthesis and Genetic Tuning of Guanine Crystals via Metabolic Engineering of Yeast.Angewandte Chemie (International ed. in English) · 2026Article
- Paralogous guanine deaminases acquired from bacteria by horizontal gene transfer promote purine homeostasis inbioRxiv : the preprint server for biology · 2026Article
- Control Strategies in Guanine Biocrystallization.Angewandte Chemie (International ed. in English) · 2026Review
- Harnessing microalgae for the biosynthesis of molecular crystals.Nature biotechnology · 2026Article
- Microalgae as cellular factories for molecular crystals.Nature biotechnology · 2026Article
- Energy metabolism and adaptation to hypoxia in the non-photosynthetic green alga Leontynka.BMC biology · 2026Article
- The Role of Confinement in Biomineralization.Chemical reviews · 2025Review
- Crystalline guanine: Rediscovery of a long-overlooked structure of unicellular eukaryotes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Underlying charge-transfer mechanism of visible light emission in guanine crystals.Communications chemistry · 2025Article
- Guanine storage vacuoles sequester guanine crystals and serve as nitrogen reserves inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Algae-dominated metaproteomes uncover cellular adaptations to life on the Greenland Ice Sheet.NPJ biofilms and microbiomes · 2025Article
- Guanine Crystallization by Particle Attachment.Journal of the American Chemical Society · 2025Article
- Specialized molecular pathways drive the formation of light-scattering assemblies in leucophores.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Impact of heterologous expression of Cannabis sativa tetraketide synthase on Phaeodactylum tricornutum metabolic profile.Biotechnology for biofuels and bioproducts · 2025Article
- Genetic control over biogenic crystal morphogenesis in zebrafish.Nature chemical biology · 2025Article
- Eating the brain - A multidisciplinary study provides new insights into the mechanisms underlying the cytopathogenicity of Naegleria fowleri.PLoS pathogens · 2025Article
- Guanine crystal formation by the unicellular organism Phacotus lenticularis is part of a cellular stress response.PloS one · 2025Article
- Review
- Temperature Dependence and the Effects of Ultraviolet Radiation on the Ultrastructure and Photosynthetic Activity of Carpospores in Sub-Antarctic Red AlgaPlants (Basel, Switzerland) · 2024Article
- Characterization of Crystals in Ciliate Paramecium bursaria Harboring Endosymbiotic Chlorella variabilis.Current microbiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitrogen (N) is an essential macronutrient for microalgae, influencing their productivity, composition, and growth dynamics. Despite the dramatic consequences of N starvation, many free-living and endosymbiotic microalgae thrive in N-poor and N-fluctuating environments, giving rise to questions about the existence and nature of their long-term N reserves. Our understanding of these processes requires a unequivocal identification of the N reserves in microalgal cells as well as their turnover kinetics and subcellular localization. Herein, we identified crystalline guanine as the enigmatic large-capacity and rapid-turnover N reserve of microalgae. The identification was unambiguously supported by confocal Raman, fluorescence, and analytical transmission electron microscopies as well as stable isotope labeling. We discovered that the storing capacity for crystalline guanine by the marine dinoflagellate
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.