SynthesisCMAJ open
Effectiveness of ambulation to prevent venous thromboembolism in patients admitted to hospital: a systematic review.
Open access · diamondAbstract readSystematic Review
In one paragraph
Synthesis in CMAJ open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Chinese expert consensus on prevention, diagnosis, and management of venous thromboembolism in adult burn patients (2024).Military Medical Research · 2025Guideline
- A meta-analysis of the effects of multimodal intervention measures on the recovery of postpartum women after cesarean section.Frontiers in medicine · 2025Pooled it
- Influence of Diabetes Mellitus on Postoperative Complications After Total Knee Arthroplasty: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2024Pooled it
- [Prevention of venous thromboembolism in orthopaedics and traumatology: Austrian interdisciplinary consensus statement 2026].Wiener klinische Wochenschrift · 2026Article
- Does earlier mobilization reduce venous thromboembolism after spine surgery?European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Minimally invasive percutaneous cannulated screw fixation for pelvic fractures: a retrospective case cohort study of clinical and radiological outcomes.Frontiers in medicine · 2026Article
- Inaccuracies of venous thromboembolism risk assessment and prevention practices among medically ill patients.Blood advances · 2025Article
- Advancements in Managing Choledocholithiasis and Acute Cholangitis in the Elderly: A Comprehensive Review.Cureus · 2025Review
- Prophylactic measures for reducing deep vein thrombosis risk in post-operative critical care patients.Bioinformation · 2025Article
- The Impact of an Early Mobility Protocol on Recovery Outcomes in Patients Undergoing Abdominal Surgeries.Cureus · 2024Article
- The Clot Stops Here: Insights Into Venous Thromboembolism Prophylaxis Adherence From Two Cases.Cureus · 2024Article
- The persian version of the fear-avoidance beliefs questionnaire among iranian post-surgery patients: a translation and psychometrics.BMC psychology · 2024Article
- Decreasing length of stay in breast reconstruction patients: A national analysis of 2019-2020.Journal of surgical oncology · 2023Article
- Association of early mobility with the incidence of deep-vein thrombosis and mortality among critically ill patients: a post hoc analysis of PREVENT trial.Critical care (London, England) · 2023Article
- Indian Society of Critical Care Medicine Consensus Statement for Prevention of Venous Thromboembolism in the Critical Care Unit.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022Article
- Predictive risk factors for venous thromboembolism in neurosurgical patients: A retrospective analysis single center cohort study.Annals of medicine and surgery (2012) · 2022Article
- Venous Thromboembolism in Rheumatoid Arthritis: The Added Effect of Disease Activity to Traditional Risk Factors.Open access rheumatology : research and reviews · 2022Review
- Physiologic and pharmacologic considerations in morbid obesity and bariatric anesthesia.Saudi journal of anaesthesiaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Brandyn D LauRussell H. Morgan Department of Radiology and Radiological Science (Lau), Johns Hopkins University School of Medicine; Armstrong Institute for Patient Safety and Quality (Lau, Holzmueller, Streiff), Johns Hopkins Medicine, Baltimore, Md.; Department of Surgery (Murphy), Indiana University, Indianapolis, Ind.; Division of Acute Care Surgery, Medical College of Wisconsin, Wauwatosa, Wis.; London Health Sciences Centre, London, Ont. and Department of Surgery, Indiana University, (Murphy; during the conduct of the study); School of Medicine (Nastasi), Stanford University, Li Ka Shing Building, Stanford, Calif.; Welch Medical Library (Seal), Johns Hopkins University School of Medicine; Department of Pharmacy (Kraus), Johns Hopkins Hospital; Division of Acute Care Surgery (Hobson, Aboagye, Haut), Department of Surgery, School of Medicine, Johns Hopkins University; Department of Nursing (Hobson), Johns Hopkins Hospital; Department of Nursing (Shaffer), Johns Hopkins Hospital; Division of Hematology (Streiff), Department of Medicine, Johns Hopkins University School of Medicine; Department of Health Policy and Management (Haut), Johns Hopkins Bloomberg School of Public Health, Baltimore, Md.
Patrick MurphyRussell H. Morgan Department of Radiology and Radiological Science (Lau), Johns Hopkins University School of Medicine; Armstrong Institute for Patient Safety and Quality (Lau, Holzmueller, Streiff), Johns Hopkins Medicine, Baltimore, Md.; Department of Surgery (Murphy), Indiana University, Indianapolis, Ind.; Division of Acute Care Surgery, Medical College of Wisconsin, Wauwatosa, Wis.; London Health Sciences Centre, London, Ont. and Department of Surgery, Indiana University, (Murphy; during the conduct of the study); School of Medicine (Nastasi), Stanford University, Li Ka Shing Building, Stanford, Calif.; Welch Medical Library (Seal), Johns Hopkins University School of Medicine; Department of Pharmacy (Kraus), Johns Hopkins Hospital; Division of Acute Care Surgery (Hobson, Aboagye, Haut), Department of Surgery, School of Medicine, Johns Hopkins University; Department of Nursing (Hobson), Johns Hopkins Hospital; Department of Nursing (Shaffer), Johns Hopkins Hospital; Division of Hematology (Streiff), Department of Medicine, Johns Hopkins University School of Medicine; Department of Health Policy and Management (Haut), Johns Hopkins Bloomberg School of Public Health, Baltimore, Md.
Anthony J NastasiRussell H. Morgan Department of Radiology and Radiological Science (Lau), Johns Hopkins University School of Medicine; Armstrong Institute for Patient Safety and Quality (Lau, Holzmueller, Streiff), Johns Hopkins Medicine, Baltimore, Md.; Department of Surgery (Murphy), Indiana University, Indianapolis, Ind.; Division of Acute Care Surgery, Medical College of Wisconsin, Wauwatosa, Wis.; London Health Sciences Centre, London, Ont. and Department of Surgery, Indiana University, (Murphy; during the conduct of the study); School of Medicine (Nastasi), Stanford University, Li Ka Shing Building, Stanford, Calif.; Welch Medical Library (Seal), Johns Hopkins University School of Medicine; Department of Pharmacy (Kraus), Johns Hopkins Hospital; Division of Acute Care Surgery (Hobson, Aboagye, Haut), Department of Surgery, School of Medicine, Johns Hopkins University; Department of Nursing (Hobson), Johns Hopkins Hospital; Department of Nursing (Shaffer), Johns Hopkins Hospital; Division of Hematology (Streiff), Department of Medicine, Johns Hopkins University School of Medicine; Department of Health Policy and Management (Haut), Johns Hopkins Bloomberg School of Public Health, Baltimore, Md.
Stella SealRussell H. Morgan Department of Radiology and Radiological Science (Lau), Johns Hopkins University School of Medicine; Armstrong Institute for Patient Safety and Quality (Lau, Holzmueller, Streiff), Johns Hopkins Medicine, Baltimore, Md.; Department of Surgery (Murphy), Indiana University, Indianapolis, Ind.; Division of Acute Care Surgery, Medical College of Wisconsin, Wauwatosa, Wis.; London Health Sciences Centre, London, Ont. and Department of Surgery, Indiana University, (Murphy; during the conduct of the study); School of Medicine (Nastasi), Stanford University, Li Ka Shing Building, Stanford, Calif.; Welch Medical Library (Seal), Johns Hopkins University School of Medicine; Department of Pharmacy (Kraus), Johns Hopkins Hospital; Division of Acute Care Surgery (Hobson, Aboagye, Haut), Department of Surgery, School of Medicine, Johns Hopkins University; Department of Nursing (Hobson), Johns Hopkins Hospital; Department of Nursing (Shaffer), Johns Hopkins Hospital; Division of Hematology (Streiff), Department of Medicine, Johns Hopkins University School of Medicine; Department of Health Policy and Management (Haut), Johns Hopkins Bloomberg School of Public Health, Baltimore, Md.
Peggy S KrausRussell H. Morgan Department of Radiology and Radiological Science (Lau), Johns Hopkins University School of Medicine; Armstrong Institute for Patient Safety and Quality (Lau, Holzmueller, Streiff), Johns Hopkins Medicine, Baltimore, Md.; Department of Surgery (Murphy), Indiana University, Indianapolis, Ind.; Division of Acute Care Surgery, Medical College of Wisconsin, Wauwatosa, Wis.; London Health Sciences Centre, London, Ont. and Department of Surgery, Indiana University, (Murphy; during the conduct of the study); School of Medicine (Nastasi), Stanford University, Li Ka Shing Building, Stanford, Calif.; Welch Medical Library (Seal), Johns Hopkins University School of Medicine; Department of Pharmacy (Kraus), Johns Hopkins Hospital; Division of Acute Care Surgery (Hobson, Aboagye, Haut), Department of Surgery, School of Medicine, Johns Hopkins University; Department of Nursing (Hobson), Johns Hopkins Hospital; Department of Nursing (Shaffer), Johns Hopkins Hospital; Division of Hematology (Streiff), Department of Medicine, Johns Hopkins University School of Medicine; Department of Health Policy and Management (Haut), Johns Hopkins Bloomberg School of Public Health, Baltimore, Md.
Deborah B HobsonRussell H. Morgan Department of Radiology and Radiological Science (Lau), Johns Hopkins University School of Medicine; Armstrong Institute for Patient Safety and Quality (Lau, Holzmueller, Streiff), Johns Hopkins Medicine, Baltimore, Md.; Department of Surgery (Murphy), Indiana University, Indianapolis, Ind.; Division of Acute Care Surgery, Medical College of Wisconsin, Wauwatosa, Wis.; London Health Sciences Centre, London, Ont. and Department of Surgery, Indiana University, (Murphy; during the conduct of the study); School of Medicine (Nastasi), Stanford University, Li Ka Shing Building, Stanford, Calif.; Welch Medical Library (Seal), Johns Hopkins University School of Medicine; Department of Pharmacy (Kraus), Johns Hopkins Hospital; Division of Acute Care Surgery (Hobson, Aboagye, Haut), Department of Surgery, School of Medicine, Johns Hopkins University; Department of Nursing (Hobson), Johns Hopkins Hospital; Department of Nursing (Shaffer), Johns Hopkins Hospital; Division of Hematology (Streiff), Department of Medicine, Johns Hopkins University School of Medicine; Department of Health Policy and Management (Haut), Johns Hopkins Bloomberg School of Public Health, Baltimore, Md.
Dauryne L ShafferRussell H. Morgan Department of Radiology and Radiological Science (Lau), Johns Hopkins University School of Medicine; Armstrong Institute for Patient Safety and Quality (Lau, Holzmueller, Streiff), Johns Hopkins Medicine, Baltimore, Md.; Department of Surgery (Murphy), Indiana University, Indianapolis, Ind.; Division of Acute Care Surgery, Medical College of Wisconsin, Wauwatosa, Wis.; London Health Sciences Centre, London, Ont. and Department of Surgery, Indiana University, (Murphy; during the conduct of the study); School of Medicine (Nastasi), Stanford University, Li Ka Shing Building, Stanford, Calif.; Welch Medical Library (Seal), Johns Hopkins University School of Medicine; Department of Pharmacy (Kraus), Johns Hopkins Hospital; Division of Acute Care Surgery (Hobson, Aboagye, Haut), Department of Surgery, School of Medicine, Johns Hopkins University; Department of Nursing (Hobson), Johns Hopkins Hospital; Department of Nursing (Shaffer), Johns Hopkins Hospital; Division of Hematology (Streiff), Department of Medicine, Johns Hopkins University School of Medicine; Department of Health Policy and Management (Haut), Johns Hopkins Bloomberg School of Public Health, Baltimore, Md.
Christine G HolzmuellerRussell H. Morgan Department of Radiology and Radiological Science (Lau), Johns Hopkins University School of Medicine; Armstrong Institute for Patient Safety and Quality (Lau, Holzmueller, Streiff), Johns Hopkins Medicine, Baltimore, Md.; Department of Surgery (Murphy), Indiana University, Indianapolis, Ind.; Division of Acute Care Surgery, Medical College of Wisconsin, Wauwatosa, Wis.; London Health Sciences Centre, London, Ont. and Department of Surgery, Indiana University, (Murphy; during the conduct of the study); School of Medicine (Nastasi), Stanford University, Li Ka Shing Building, Stanford, Calif.; Welch Medical Library (Seal), Johns Hopkins University School of Medicine; Department of Pharmacy (Kraus), Johns Hopkins Hospital; Division of Acute Care Surgery (Hobson, Aboagye, Haut), Department of Surgery, School of Medicine, Johns Hopkins University; Department of Nursing (Hobson), Johns Hopkins Hospital; Department of Nursing (Shaffer), Johns Hopkins Hospital; Division of Hematology (Streiff), Department of Medicine, Johns Hopkins University School of Medicine; Department of Health Policy and Management (Haut), Johns Hopkins Bloomberg School of Public Health, Baltimore, Md.
Jonathan K AboagyeRussell H. Morgan Department of Radiology and Radiological Science (Lau), Johns Hopkins University School of Medicine; Armstrong Institute for Patient Safety and Quality (Lau, Holzmueller, Streiff), Johns Hopkins Medicine, Baltimore, Md.; Department of Surgery (Murphy), Indiana University, Indianapolis, Ind.; Division of Acute Care Surgery, Medical College of Wisconsin, Wauwatosa, Wis.; London Health Sciences Centre, London, Ont. and Department of Surgery, Indiana University, (Murphy; during the conduct of the study); School of Medicine (Nastasi), Stanford University, Li Ka Shing Building, Stanford, Calif.; Welch Medical Library (Seal), Johns Hopkins University School of Medicine; Department of Pharmacy (Kraus), Johns Hopkins Hospital; Division of Acute Care Surgery (Hobson, Aboagye, Haut), Department of Surgery, School of Medicine, Johns Hopkins University; Department of Nursing (Hobson), Johns Hopkins Hospital; Department of Nursing (Shaffer), Johns Hopkins Hospital; Division of Hematology (Streiff), Department of Medicine, Johns Hopkins University School of Medicine; Department of Health Policy and Management (Haut), Johns Hopkins Bloomberg School of Public Health, Baltimore, Md.
Michael B StreiffRussell H. Morgan Department of Radiology and Radiological Science (Lau), Johns Hopkins University School of Medicine; Armstrong Institute for Patient Safety and Quality (Lau, Holzmueller, Streiff), Johns Hopkins Medicine, Baltimore, Md.; Department of Surgery (Murphy), Indiana University, Indianapolis, Ind.; Division of Acute Care Surgery, Medical College of Wisconsin, Wauwatosa, Wis.; London Health Sciences Centre, London, Ont. and Department of Surgery, Indiana University, (Murphy; during the conduct of the study); School of Medicine (Nastasi), Stanford University, Li Ka Shing Building, Stanford, Calif.; Welch Medical Library (Seal), Johns Hopkins University School of Medicine; Department of Pharmacy (Kraus), Johns Hopkins Hospital; Division of Acute Care Surgery (Hobson, Aboagye, Haut), Department of Surgery, School of Medicine, Johns Hopkins University; Department of Nursing (Hobson), Johns Hopkins Hospital; Department of Nursing (Shaffer), Johns Hopkins Hospital; Division of Hematology (Streiff), Department of Medicine, Johns Hopkins University School of Medicine; Department of Health Policy and Management (Haut), Johns Hopkins Bloomberg School of Public Health, Baltimore, Md.
Elliott R HautRussell H. Morgan Department of Radiology and Radiological Science (Lau), Johns Hopkins University School of Medicine; Armstrong Institute for Patient Safety and Quality (Lau, Holzmueller, Streiff), Johns Hopkins Medicine, Baltimore, Md.; Department of Surgery (Murphy), Indiana University, Indianapolis, Ind.; Division of Acute Care Surgery, Medical College of Wisconsin, Wauwatosa, Wis.; London Health Sciences Centre, London, Ont. and Department of Surgery, Indiana University, (Murphy; during the conduct of the study); School of Medicine (Nastasi), Stanford University, Li Ka Shing Building, Stanford, Calif.; Welch Medical Library (Seal), Johns Hopkins University School of Medicine; Department of Pharmacy (Kraus), Johns Hopkins Hospital; Division of Acute Care Surgery (Hobson, Aboagye, Haut), Department of Surgery, School of Medicine, Johns Hopkins University; Department of Nursing (Hobson), Johns Hopkins Hospital; Department of Nursing (Shaffer), Johns Hopkins Hospital; Division of Hematology (Streiff), Department of Medicine, Johns Hopkins University School of Medicine; Department of Health Policy and Management (Haut), Johns Hopkins Bloomberg School of Public Health, Baltimore, Md. ehaut1@jhmi.edu.
Johns Hopkins University · USIndiana University – Purdue University Indianapolis · US
Funding
Analysis of the impact of missed doses of venous thromboembolism prophylaxisR21HL129028 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI LAU, BRANDYN DANIEL · 2017 to 2018
$245kAHRQ HHS R01 HS024547AHRQ HHS R18 HS027415NHLBI NIH HHS R21 HL129028Patient-Centered Outcomes Research Institute CE-12-11-4489
Abstract
backgroundPatient ambulation is frequently recommended to help prevent venous thromboembolism during hospital admission. Our objective was to synthesize the evidence for ambulation as a prophylaxis for venous thromboembolism in hospital.
methodsWe conducted a systematic review. We searched MEDLINE, Embase, Scopus, Web of Science and Cochrane Central Register of Controlled Trials indexed from their inception through April 2020 for studies of adult patients admitted to hospital, in which ambulation or mobilization alone or concomitant with prophylaxis was indicated for prevention of venous thromboembolism. We searched ClinicalTrials.gov for unpublished trials. We included randomized controlled trials (RCTs) and observational studies. Two reviewers independently screened articles and assessed risk of bias using 2 validated tools. We scored studies on quality of reporting, internal and external validity and study power; combined scores determined the overall quality.
resultsEighteen articles met the inclusion criteria: 8 retrospective and 2 prospective cohorts, 7 RCTs and 1 secondary analysis of an RCT. The intervention (ambulation or mobilized) groups varied across studies. Five studies examined exercise as a therapeutic prophylaxis for thrombosis and 9 described an ambulation protocol. Five studies attempted to quantify amount and duration of patient ambulation and 3 reported ambulation distance. In the 5 studies rated as good or excellent statistical quality, findings were mixed. Incidence of venous thromboembolism was lowest when pharmacologic anticoagulants were added as part of the prescribed prophylaxis regimen.
interpretationWe did not find high-quality evidence supporting ambulation alone as an effective prophylaxis for venous thromboembolism. Ambulation should not be considered an adequate prophylaxis for venous thromboembolism, nor as an adequate reason to discontinue pharmacologic prophylaxis for venous thromboembolism during a patient's hospital admission.
Indexed as
WalkingAnticoagulantsHospitalizationHumansRandomized Controlled Trials as TopicVenous ThromboembolismAnticoagulants
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.