ArticleBMJ open diabetes research & care2020
Association of physical activity and sedentary behavior with type 2 diabetes and glycemic traits: a two-sample Mendelian randomization study.
Article in BMJ open diabetes research & care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Causal Association Between Sedentary Behaviors and Health Outcomes: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- Polygenic risk and air pollution trends in relation to type 2 diabetes: evidence from the Taiwan Biobank.Diabetology & metabolic syndrome · 2026Article
- Effects of Iron, Copper, Zinc, and Magnesium on Chronic Widespread Pain: A Two-Sample Mendelian Randomization.Journal of clinical medicine · 2024Article
- Physical activity and the risk of developing 8 age-related diseases: epidemiological and Mendelian randomization studies.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2024Article
- Rheumatoid arthritis increases the risk of malignant neoplasm of bone and articular cartilage: a two-sample bidirectional mendelian randomization study.Arthritis research & therapy · 2023Article
- Systematic comparison of Mendelian randomisation studies and randomised controlled trials using electronic databases.BMJ open · 2023Article
- Physical Activity, Sedentary Behavior, and Type 2 Diabetes: Mendelian Randomization Analysis.Journal of the Endocrine Society · 2023Article
- Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges.Diabetologia · 2023Review
- Genetic causal relationship between age at menarche and benign oesophageal neoplasia identified by a Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Causal association of physical activity with low back pain, intervertebral disc degeneration and sciatica: a two-sample mendelian randomization analysis study.Frontiers in cell and developmental biology · 2023Article
- Exercise sustains the hallmarks of health.Journal of sport and health science · 2023Review
- Association between physical activity and insulin resistance using the homeostatic model assessment for insulin resistance independent of waist circumference.Scientific reports · 2022Article
- Physical activity, sedentary behavior, and the risk of type 2 diabetes: A two-sample Mendelian Randomization analysis in the European population.Frontiers in endocrinology · 2022Article
- Causal Relationships Between Total Physical Activity and Ankylosing Spondylitis: A Mendelian Randomization Study.Frontiers in immunology · 2022Article
- Shared Genetic Basis and Causal Relationship Between Television Watching, Breakfast Skipping and Type 2 Diabetes: Evidence From a Comprehensive Genetic Analysis.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
introductionObservational studies suggest that physical activity lowers and sedentary behavior increases the risk of type 2 diabetes. Despite of some supportive trial data for physical activity, it is largely unresolved whether these relations are causal or due to bias.
objectiveWe investigated the associations between accelerometer-based physical activity and sedentary behavior with type 2 diabetes and several glycemic traits using two-sample Mendelian randomization analysis. RESEARCH DESIGN AND
methodsSingle nucleotide polymorphisms (SNPs) associated at p<5×10 OUTCOMES: Type 2 diabetes, hemoglobin A1c (HbA1c), fasting glucose, homeostasis model assessment of beta-cell function (HOMA-B), and homeostasis model assessment of insulin resistance (HOMA-IR).
resultsPhysical activity and sedentary behavior were unrelated to type 2 diabetes, HbA1c, fasting glucose, HOMA-B, and HOMA-IR. The inverse variance weighted ORs per SD increment for the association between average accelerations and vigorous physical activity with type 2 diabetes were 1.00 (95% CI 0.94 to 1.07, p=0.948) and 0.83 (95% CI 0.56 to 1.23, p=0.357), respectively. These results were confirmed by sensitivity analyses using alternative MR-methods to test the robustness of our findings.
conclusionsBased on these results, genetically predicted objectively measured average or vigorous physical activity and sedentary behavior is not associated with type 2 diabetes risk or with glycemic traits in the general population. Further research is required to deepen the understanding of the biological pathways of physical activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.