Evidence map›Paper›PMID 33292897›Full record

ArticleJournal of the International Neuropsychological Society : JINS2021

Mediators and Moderators of the Association Between Perceived Stress and Episodic Memory in Diverse Older Adults.

Afsara B Zaheed, Neika Sharifian, A Zarina Kraal, Ketlyne Sol, Jennifer J Manly, Nicole Schupf, Adam M Brickman, Laura B Zahodne

Abstract read
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Chronic stress, social support, and domain-specific cognitive decline in HABS-HD.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Interpersonal, Community, and Societal Stressors Mediate Black-White Memory Disparities.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Afsara B ZaheedDepartment of Psychology, University of Michigan, 530 Church St., Ann Arbor, MI48109, USA.ORCID 0000-0002-2872-6896
Neika SharifianDepartment of Psychology, University of Michigan, 530 Church St., Ann Arbor, MI48109, USA.ORCID 0000-0003-3985-8963
A Zarina KraalDepartment of Psychology, University of Michigan, 530 Church St., Ann Arbor, MI48109, USA.
Ketlyne SolDepartment of Psychology, University of Michigan, 530 Church St., Ann Arbor, MI48109, USA.
Jennifer J ManlyTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, 710 West 168th Street, 3rd floor, New York, NY10032, USA.ORCID 0000-0002-9481-7497
Nicole SchupfTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, 710 West 168th Street, 3rd floor, New York, NY10032, USA.
Adam M BrickmanTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, 710 West 168th Street, 3rd floor, New York, NY10032, USA.ORCID 0000-0002-5125-8226
Laura B ZahodneDepartment of Psychology, University of Michigan, 530 Church St., Ann Arbor, MI48109, USA.ORCID 0000-0002-5763-4501

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Andrew Franklin Teich · 2020 to 2026
$30.1M
VASCULAR FACTORS AND MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASEP01AG007232 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI LUCHSINGER, JOSE ALEJANDRO · 1989 to 2008
$21.7M
Epidemiology of Biomarkers of Risk and Progression in LOADR01AG037212 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, SCHUPF, NICOLE · 2010 to 2015
$10.1M
Genetic Epidemiology of Cerebrovascular Factors in Alzheimer's DiseaseRF1AG054023 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2016 to 2018
$8.9M
Resilience Mechanisms Underlying Racial/Ethnic Disparities in Alzheimer’s DiseaseR01AG054520 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, ZAHODNE, LAURA B · 2017 to 2021
$5.8M
Psychosocial Protective Factors in Cognitive and Brain AgingR00AG047963 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZAHODNE, LAURA B · 2016 to 2018
$746k
NCATS NIH HHS UL1 TR001873NIA NIH HHS P01 AG007232NIA NIH HHS P30 AG066462NIA NIH HHS R00 AG047963NIA NIH HHS R01 AG037212NIA NIH HHS R01 AG054520NIA NIH HHS RF1 AG054023
6 · The paper itself

Abstract

objectiveStress is a risk factor for numerous negative health outcomes, including cognitive impairment in late-life. The negative association between stress and cognition may be mediated by depressive symptoms, which separate studies have identified as both a consequence of perceived stress and a risk factor for cognitive decline. Pathways linking perceived stress, depressive symptoms, and cognition may be moderated by sociodemographics and psychosocial resources. The goal of this cross-sectional study was to identify modifying factors and enhance understanding of the mechanisms underlying the stress-cognition association in a racially and ethnically diverse sample of older adults.

methodA linear regression estimated the association between perceived stress and episodic memory in 578 older adults (Mage = 74.58) in the Washington Heights-Inwood Columbia Aging Project. Subsequent models tested whether depressive symptoms mediated the stress-memory relationship and whether sociodemographics (gender, race, and ethnicity) or perceived control moderated these pathways.

resultsIndependent of sociodemographics and chronic diseases, greater perceived stress was associated with worse episodic memory. This relationship was mediated by more depressive symptoms. Higher perceived control buffered the association between stress and depressive symptoms. There was no significant moderation by gender, race, or ethnicity.

conclusionDepressive symptoms may play a role in the negative association between perceived stress and cognition among older adults; however, longitudinal analyses and studies using experimental designs are needed. Perceived control is a modifiable psychological resource that may offset the negative impact of stress.

Indexed as

Memory, EpisodicAgedAgingCognitionCross-Sectional StudiesDepressionHumansStress, PsychologicalCognitive agingDepressive symptomsPsychological stressSense of control

Identifiers

PMID33292897
PMCPMC8187476

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.