ArticleBioelectronic medicine2020
Autonomic balance determines the severity of COVID-19 courses.
Article in Bioelectronic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- A cross sectional study of the autonomic function at different recovery phases in SARS-CoV-2 patients without orthostatic symptoms.Scientific reports · 2026Article
- Classification of Individuals With COVID-19 and Post-COVID-19 Condition and Healthy Controls Using Heart Rate Variability: Machine Learning Study With a Near-Real-Time Monitoring Component.Journal of medical Internet research · 2025Article
- The impact of long COVID on heart rate variability: a cross-sectional study.BMC infectious diseases · 2025Article
- Impact of COVID-19 on heart rate variability in post-COVID individuals compared to a control group.Scientific reports · 2024Article
- Autonomic Imbalance and Elevated Inflammatory Cytokines in Long COVID: A Cross-Sectional Study.Cureus · 2024Article
- Cardiac Autonomic Function and Functional Capacity in Post-COVID-19 Individuals with Systemic Arterial Hypertension.Journal of personalized medicine · 2023Article
- Autonomic modulation, spontaneous baroreflex sensitivity and fatigue in young men after COVID-19.Physiological research · 2023Article
- Assessment and Therapeutic Modulation of Heart Rate Variability: Potential Implications in Patients with COVID-19.Journal of cardiovascular development and disease · 2023Review
- Post-COVID Dysautonomias: The Importance of Early Recognition and Implementation of Recovery Programs.Arquivos brasileiros de cardiologia · 2023Article
- Is the post-COVID-19 syndrome a severe impairment of acetylcholine-orchestrated neuromodulation that responds to nicotine administration?Bioelectronic medicine · 2023Article
- Neural dysregulation in post-COVID fatigue.Brain communications · 2023Article
- The diversity of neuroimmune circuits controlling lung inflammation.American journal of physiology. Lung cellular and molecular physiology · 2023Review
- Investigating autonomic nervous system dysfunction among patients with post-COVID condition and prolonged cardiovascular symptoms.Frontiers in medicine · 2023Article
- Autonomic dysfunction in COVID-19 patients receiving mechanical ventilation: A cross-sectional study.Sao Paulo medical journal = Revista paulista de medicina · 2023Article
- Understanding the Pivotal Role of the Vagus Nerve in Health from Pandemics.Bioengineering (Basel, Switzerland) · 2022Article
- A case report of severe cardioinhibitory reflex syncope associated with coronavirus disease 2019.European heart journal. Case reports · 2022Article
- Orthostatic Intolerance in Adults Reporting Long COVID Symptoms Was Not Associated With Postural Orthostatic Tachycardia Syndrome.Frontiers in physiology · 2022Article
- Kinetics of Severity Biomarkers and Immunological Features of Methylprednisolone Therapy for Severe COVID-19 Patients.Frontiers in immunology · 2022Article
- Coagulopathies after Vaccination against SARS-CoV-2 May Be Derived from a Combined Effect of SARS-CoV-2 Spike Protein and Adenovirus Vector-Triggered Signaling Pathways.International journal of molecular sciences · 2021Review
- Day-to-day blood pressure variability and severity of COVID-19: Is sympathetic overdrive a potential link?Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
COVID-19 has left mankind desperately seeking how to manage dramatically rising infection rates associated with severe disease progressions. COVID-19 courses range from mild symptoms up to multiple organ failure and death, triggered by excessively high serum cytokine levels (IL 1β, IL 6, TNF α, IL 8). The vagally driven cholinergic anti-inflammatory pathway (CAP) stops the action of nuclear factor κB (NF-κB), the transcriptional factor of pro-inflammatory cytokines. Thus, well-balanced cytokine release depends on adequate vagal signaling. Coronaviruses replicate using NF-κB transcriptional factor as well. By degrading the cytoplasmatic inhibitor of NF-κB subunits (IκB), coronaviruses induce unrestricted NF-κB expression accelerating both, virus replication and cytokine transcription.We hypothesize that CAP detriment due to depressed vagal tone critically determines the severity of COVID-19.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.