ArticleBMC rheumatology2020
Prognostic factors for the short-term mortality of patients with rheumatoid arthritis admitted to intensive care units.
Article in BMC rheumatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 17 citations in OpenAlex.
- Machine learning-based prediction of 30-day mortality in critically ill patients with rheumatoid arthritis.Clinical rheumatology · 2026Article
- Explainable machine learning-based mortality prediction in critically ill patients with rheumatoid arthritis-associated lung disease: a radiomics and clinical data integration study.BMC medical imaging · 2026Article
- Non-linear association of admission platelet-to-lymphocyte ratio with 28- and 90-day mortality in critically ill patients with rheumatoid arthritis: a retrospective cohort study.Clinical rheumatology · 2026Article
- The Interplay Between Rheumatoid Arthritis and Chronic Kidney Disease: From Mechanisms to Treatment.Journal of clinical medicine · 2025Review
- Intensive care unit admission and mortality in rheumatic diseases.Rheumatology international · 2025Review
- Explainable machine learning model for prediction of 28-day all-cause mortality in immunocompromised patients in the intensive care unit: a retrospective cohort study based on MIMIC-IV database.European journal of medical research · 2025Article
- Decreased in-hospital mortality in shock patients with rheumatoid arthritis compared to those without: a retrospective analysis of a critical care database.Clinical rheumatology · 2025Observational
- First Metatarsophalangeal Joint-Preserving Surgery Is Effective for Forefoot Deformity With Moderate to Severe Joint Destruction in Rheumatoid Arthritis.Foot & ankle orthopaedics · 2025Article
- A Review of the Current Status of Anesthetic Management of Patients with Rheumatoid Arthritis.Medical science monitor : international medical journal of experimental and clinical research · 2024Review
- Mortality Trends Among Patients with Rheumatoid Arthritis in Western Australia.Rheumatology and therapy · 2023Article
- Determination of the main causes, outcome, and prognostic factors of patients with rheumatologic diseases admitted to the medical intensive care unit in Southern Iran.Clinical rheumatology · 2022Article
- Factors affecting patient satisfaction related to cost and treatment effectiveness in rheumatoid arthritis: results from the multicenter observational cohort study, FRANK Registry.Arthritis research & therapy · 2022Observational
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPatients with rheumatoid arthritis (RA) have high mortality risk and are frequently treated in intensive care units (ICUs).
methodsThis was a retrospective observational study. This study included 67 patients (20 males, 47 females) with RA who were admitted at the ICU of our institution for ≥48 h between January 2008 and December 2017. We analyzed the 30-day mortality of these patients and the investigated prognostic factors in RA patients admitted to our ICU.
resultsUpon admission, the median age was 70 (range, 33-96) years, and RA duration was 10 (range, 0-61) years. The 5-year survival after ICU admission was 47%, and 30-day, 90-day, and 1-year mortality rates were 22, 27, and 37%, respectively. The major reasons for ICU admission were cardiovascular complications (24%) and infection (40%) and the most common ICU treatments were mechanical ventilation (69%), renal replacement (25%), and vasopressor (78%). In the 30-day mortality group, infection led to a fatal outcome in most cases (67%), and nonsurvival was associated with a significantly higher glucocorticoid dose, updated Charlson's comorbidity index (CCI), and acute physiology and chronic health evaluation (APACHE) II score. Laboratory data obtained at ICU admission showed that lower platelet number and total protein and higher creatinine and prothrombin time international normalized ratio (PT-INR) indicated significantly poorer prognosis. The multivariate Cox proportional hazard model revealed that nonuse of csDMARDs, high updated CCI, increased APACHE II score, and prolonged PT-INR were associated with a higher risk of mortality after ICU admission.
conclusionOur study demonstrated that the nonuse of csDMARDs, high updated CCI, elevated APACHE II score, and coagulation abnormalities predicted poorer prognosis in RA patients admitted to the ICU.
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