Evidence map›Paper›PMID 33292822›Full record

ArticlePneumonia (Nathan Qld.)2020

An observational study of the reactogenicity and immunogenicity of 13-valent pneumococcal conjugate vaccine in women of childbearing age in Papua New Guinea.

Sarah Javati, Geraldine Masiria, Arthur Elizah, John-Paul Matlam, Rebecca Ford, Peter C Richmond, Deborah Lehmann, William S Pomat, Anita H J van den Biggelaar

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pneumonia (Nathan Qld.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04183322 (Reactogenicity and Immunogenicity of Pneumococcal Conjugate Vaccination in Non-pregnant Papua New Guinean Women), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04183322 completednot on this map

Reactogenicity and Immunogenicity of Pneumococcal Conjugate Vaccination in Non-pregnant Papua New Guinean Women

TypeobservationalSponsorTelethon Kids InstituteRan2016 to 2018Enrolled50ConditionsPneumococcal InfectionsArms13-valent pneumococcal conjugate vaccine
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Sarah JavatiPapua New Guinea Institute of Medical Research, Homate Street, Goroka, Eastern Highlands Province, 441, Papua New Guinea.
Geraldine MasiriaPapua New Guinea Institute of Medical Research, Homate Street, Goroka, Eastern Highlands Province, 441, Papua New Guinea.
Arthur ElizahPapua New Guinea Institute of Medical Research, Homate Street, Goroka, Eastern Highlands Province, 441, Papua New Guinea.
John-Paul MatlamPapua New Guinea Institute of Medical Research, Homate Street, Goroka, Eastern Highlands Province, 441, Papua New Guinea.
Rebecca FordPapua New Guinea Institute of Medical Research, Homate Street, Goroka, Eastern Highlands Province, 441, Papua New Guinea.
Peter C RichmondDivision of Pediatrics, School of Medicine, Perth Children's Hospital, University of Western Australia, 15 Hospital Avenue, Nedlands, WA, 6009, Australia.
Deborah LehmannWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute and Centre for Child Health Research, University of Western Australia, 15 Hospital Avenue, Nedlands, WA, 6009, Australia.
William S PomatPapua New Guinea Institute of Medical Research, Homate Street, Goroka, Eastern Highlands Province, 441, Papua New Guinea.
Anita H J van den BiggelaarWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute and Centre for Child Health Research, University of Western Australia, 15 Hospital Avenue, Nedlands, WA, 6009, Australia. Anita.vandenbiggelaar@telethonkids.org.au.
Papua New Guinea Institute of Medical Research · PGUniversity of Western Australia · AUThe Kids Research Institute Australia · AU

Funding

Telethon Kids Institute Infectious Diseases Research Focus Area Working Group, Seed Funding Award
6 · The paper itself

Abstract

backgroundMaternal immunization with pneumococcal conjugate vaccine (PCV) may protect young infants in high-risk settings against the high risk of pneumococcal infections in early life. The aim of this study was to determine the safety and immunogenicity of 13-valent PCV (PCV13) in healthy women of childbearing age in PNG.

methodsAs part of this observational study, 50 non-pregnant women of childbearing age (18-45 yrs. old) living in the highlands of PNG were vaccinated with a single dose of PCV13. Local and systemic reactogenicity were assessed 24-48 h after vaccination. Venous blood samples were collected before and 1 month after vaccination to measure PCV13 serotype-specific IgG antibody concentrations.

resultsNo severe adverse effects were reported during the 1-month follow-up period. IgG antibody concentrations significantly increased after vaccination for all PCV13 serotypes. One month after vaccination IgG antibody levels ≥2.5 μg/mL were reached in at least 75% of women for all PCV13 serotypes, except serotype 3, and ≥ 5 μg/mL in at least 75% of women for 7 serotypes (serotypes 6B, 9 V, 14, 18C, 19A, 19F and 23F).

conclusionPCV13 is safe and immunogenic in women of childbearing age living in a high-risk setting in PNG. This supports the implementation of studies to investigate the safety and immunogenicity of maternal PCV vaccination in high-risk settings as a strategy to protect infants in these settings against the high risk of pneumococcal infections in early life.

trial registrationNCT04183322 . Registered 3 December 2019 - Retrospectively registered.

Indexed as

AdultsChildbearing ageImmunogenicityNon-pregnantPapua New GuineaPCVPneumococcalPneumococcal conjugate vaccineSafetyVaccineWOCBA

Identifiers

PMID33292822
PMCPMC7687988
OpenAlexW3109974342

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.