SynthesisGlobal health research and policy2020
Geographical distribution of hyperuricemia in mainland China: a comprehensive systematic review and meta-analysis.
Synthesis in Global health research and policy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07004231 (Using Gout Buddy to Enhance Dietary Literacy and Gout Management-A Mixed Method Clinical Trial), which is not on this map. Cited by 59 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Using Gout Buddy to Enhance Dietary Literacy and Gout Management-A Mixed Method Clinical Trial
Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- A metabolomic signatures in hyperuricemia: a systematic review.Metabolomics : Official journal of the Metabolomic Society · 2026Pooled it
- Urate-lowering effects of polyphenolic compounds in animal models: systematic review and meta-analysis.PeerJ · 2025Pooled it
- Multi-target effects of Limosilactobacillus reuteri RE225 on hyperuricemia through xanthine oxidase inhibition, nucleoside degradation, gut microbiota modulation, and renal TLR4-NF-κB suppression.Journal of the science of food and agriculture · 2026Article
- Neuregulin 4-dependent MAPK amplification mediates urate-induced β-cell dysfunction.Journal of diabetes investigation · 2026Article
- The Dual Role of Exosomes in Gout: From Inflammatory Amplifiers to Therapeutic Regulators.Inflammation · 2026Review
- Genetic Association Between Sex Hormones, Serum Urate, and Gout: A Comprehensive Mendelian Randomization Study.International journal of endocrinology · 2026Article
- Preliminary analysis of lifestyle and genetic factors for hyperuricemia and gout prevalence in the Yunnan Miao population of China.Frontiers in genetics · 2026Article
- Therapeutic potential of traditional Chinese medicine for hyperuricemia: mechanistic insights and clinical prospects.Frontiers in pharmacology · 2026Review
- Metabolic Dysfunction Outweighs Inflammatory Burden in Association with Hyperuricemia: A Cross-Sectional Study in a Large Health Examination Cohort.International journal of general medicine · 2026Article
- Association between numbing-spicy related dietary behavior and hyperuricemia in a Southwestern Chinese population.Frontiers in nutrition · 2026Article
- Article
- Firsekibart versus compound betamethasone in acute gout patients unsuitable for standard therapy: A randomized phase 3 trial.Innovation (Cambridge (Mass.)) · 2025Article
- Association between Life's Essential 8 and hyperuricemia in the Chinese elderly.Asia Pacific journal of clinical nutrition · 2025Article
- Dioscin regulates oxidative stress and autophagy in uric acid-induced HK-2 cells through the P62-KEAP1-NRF2 signaling pathway.BMC nephrology · 2025Article
- Whole-genome analysis of Bacillus paranthracis YC06 isolated from healthy individual feces for biodegrading inosine and guanosine.BMC microbiology · 2025Article
- Association between the combination of the triglyceride-glucose index and obesity-related indices with hyperuricemia among children and adolescents in China.Lipids in health and disease · 2025Article
- Genome Analysis and In Vitro Assay of Probiotic Properties ofMicroorganisms · 2025Article
- Association Between TyG-BMI Index and Hyperuricemia in Adult Women.Endocrinology, diabetes & metabolism · 2025Article
- The dose-response relationship and gender differences of serum uric acid with total cholesterol: a cross-sectional study.The Journal of international medical research · 2025Article
- Systemic inflammatory indices mediate the association between hyperuricemia and left ventricular hypertrophy: evidence from a single-center retrospective cross-sectional study.Frontiers in endocrinology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFructose plays an important role in the complex metabolism of uric acid in the human body. However, high blood uric acid concentration, known as hyperuricemia, is the main risk factor for development of gout. Therefore, we conducted an updated meta-analysis on the prevalence and geographical distribution of hyperuricemia among the general population in mainland China using systematic literature search.
methodsFive electronic databases were used to search for relevant articles published until 2019. All calculations were conducted using the Comprehensive Meta-Analysis (CMA) software. We included 108 eligible articles (172 studies by sex, 95 studies by regions, and 107 studies by study type) and an overall sample size of > 808,505 participants.
resultsThe pooled prevalence of hyperuricemia among the general population in mainland China was 17.4% (95% CI: 15.8-19.1%). Our subgroup analysis indicated that the pooled prevalence by regions ranged from 15.5 to 24.6%. Those living Northeast region and being males had the highest prevalence (P < 0.001). In addition, some provinces in South Central, East and Northeast regions reported a high prevalence (> 20%), particularly in males. An increasing prevalence was reported since 2005-2009 until 2015-2019. No publication of bias was observed as indicated by a symmetrical funnel plot and Begg and Mazumdar rank correlation (P = 0.392).
conclusionPrevalence of hyperuricemia is increasing in China, and future studies should investigate the association between the prevalence of hyperuricemia and its risk factors in order to tackle the issue, particularly among the vulnerable groups. Also, our study was the first comprehensive study to investigate the overall prevalence of hyperuricemia in mainland China covering the six different regions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.