ArticleGenes and environment : the official journal of the Japanese Environmental Mutagen Society2020
Screening for Ames mutagenicity of food flavor chemicals by (quantitative) structure-activity relationship.
Article in Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Synthesis and mutagenic risk of avanafil's potential genotoxic impurities.RSC advances · 2024Article
- In Vitro Investigation of the Anticancer Properties of Ammodaucus LeucotrichusPharmaceuticals (Basel, Switzerland) · 2022Article
- Genotoxicity assessment of food-flavoring chemicals used in Japan.Toxicology reports · 2022Article
- In vivo and in vitro mutagenicity of perillaldehyde and cinnamaldehyde.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021Article
- Development of a new quantitative structure-activity relationship model for predicting Ames mutagenicity of food flavor chemicals using StarDrop™ auto-Modeller™.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background(Quantitative) Structure-Activity Relationship ((Q)SAR) is a promising approach to predict the potential adverse effects of chemicals based on their structure without performing toxicological studies. We evaluate the mutagenicity of food flavor chemicals by (Q) SAR tools, identify potentially mutagenic chemicals, and verify their mutagenicity by actual Ames test.
resultsThe Ames mutagenicity of 3942 food flavor chemicals was predicted using two (Q)SAR) tools, DEREK Nexus and CASE Ultra. Three thousand five hundred seventy-five chemicals (91%) were judged to be negative in both (Q) SAR tools, and 75 chemicals (2%) were predicted to be positive in both (Q) SAR tools. When the Ames test was conducted on ten of these positive chemicals, nine showed positive results.
conclusionThe (Q) SAR method can be used for screening the mutagenicity of food flavors.
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