ArticleJournal of animal science and biotechnology2020
Inhibition of African swine fever virus in liquid and feed by medium-chain fatty acids and glycerol monolaurate.
Article in Journal of animal science and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 77 citations in OpenAlex.
- Lauric Acid and Glycerol Monolaurate Inhibit the Activity of Cyprinid Herpesvirus 2 and Enhance Host Immune Reaction.Journal of fish diseases · 2026Article
- In Vitro and In Vivo Antiviral Activity of a Modified Medium-Chain Fatty Acid Against Porcine Reproductive and Respiratory Syndrome Virus.Pathogens (Basel, Switzerland) · 2026Article
- Natural Products as Potential Resource Library for Control of Major Swine Enteric Viruses.Transboundary and emerging diseases · 2026Review
- Dietary glycerol monolaurate mitigates heat stress-induced disruption of intestinal homeostasis and hepatic lipid metabolism in laying hens.Stress biology · 2025Article
- Article
- Effects of dietary glycerol monolaurate supplementation on milk production and methane emissions in Holstein dairy cows.JDS communications · 2025Article
- Maternal consumption of glycerol monolaurate optimizes milk fatty acid profile and enhances piglet gut health in association with G protein-coupled receptor 84 (GPR84) activation.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Feeding Sows with Multi-Species Probiotics During Late Pregnancy and the Lactating Period Influences IgA Concentration in Colostrum and Subsequently Increases the Survival Rate of Piglets in Porcine Epidemic Diarrhea Outbreak Herd.Animals : an open access journal from MDPI · 2025Article
- Development of a water-dispersible antimicrobial lipid mixture to inhibit African swine fever virus and other enveloped viruses.Virus research · 2025Article
- Mitigation Strategies for African Swine Fever Virus Biosecurity: From Virus Inactivation to Pig Health.Transboundary and emerging diseases · 2025Review
- Antiviral Activity of Plant-Based Additives Against African Swine Fever Virus (ASFV) in Feed Ingredients.Veterinary medicine and science · 2024Article
- Antiviral screening of natural, anti-inflammatory compound library against African swine fever virus.Virology journal · 2024Article
- Use of Monoglycerides and Diglycerides to Mitigate Poultry Production Losses: A Review.Veterinary sciences · 2024Review
- Stability of a surrogate African swine fever-like algal virus in corn- and soybean-based feed ingredients during extended storage andFrontiers in veterinary science · 2024Article
- Postmanufacturing techniques for mitigation of viral pathogens in porcine-derived feed ingredients: a review.Translational animal science · 2024Article
- Antimicrobial and antiviral evaluation of compounds fromRSC advances · 2023Article
- Glycerol Monolaurate Inhibits Wild-Type African Swine Fever Virus Infection in Porcine Macrophages.Pathogens (Basel, Switzerland) · 2023Article
- Biosecurity and Mitigation Strategies to Control Swine Viruses in Feed Ingredients and Complete Feeds.Animals : an open access journal from MDPI · 2023Review
- Unraveling Membrane-Disruptive Properties of Sodium Lauroyl Lactylate and Its Hydrolytic Products: A QCM-D and EIS Study.International journal of molecular sciences · 2023Article
- Supplementation with alpha-glycerol monolaurate during late gestation and lactation enhances sow performance, ameliorates milk composition, and improves growth of suckling piglets.Journal of animal science and biotechnology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ongoing African swine fever virus (ASFv) epidemic has had a major impact on pig production globally and biosecurity efforts to curb ASFv infectivity and transmission are a high priority. It has been recently identified that feed and feed ingredients, along with drinking water, can serve as transmission vehicles and might facilitate transboundary spread of ASFv. Thus, it is important to test the antiviral activity of regulatory compatible, antiviral feed additives that might inhibit ASFv infectivity in feed. One promising group of feed additive candidates includes medium-chain fatty acids (MCFA) and monoglyceride derivatives, which are known to disrupt the lipid membrane surrounding certain enveloped viruses and bacteria.
resultsThe antiviral activities of selected MCFA, namely caprylic, capric, and lauric acids, and a related monoglyceride, glycerol monolaurate (GML), to inhibit ASFv in liquid and feed conditions were investigated and suitable compounds and inclusion rates were identified that might be useful for mitigating ASFv in feed environments. Antiviral assays showed that all tested MCFA and GML inhibit ASFv. GML was more potent than MCFA because it worked at a lower concentration and inhibited ASFv due to direct virucidal activity along with one or more other antiviral mechanisms. Dose-dependent feed experiments further showed that sufficiently high GML doses can significantly reduce ASFv infectivity in feed in a linear manner in periods as short as 30 min, as determined by infectious viral titer measurements. Enzyme-linked immunosorbent assay (ELISA) experiments revealed that GML treatment also hinders antibody recognition of the membrane-associated ASFv p72 structural protein, which likely relates to protein conformational changes arising from viral membrane disruption.
conclusionTogether, the findings in this study indicate that MCFA and GML inhibit ASFv in liquid conditions and that GML is also able to reduce ASFv infectivity in feed, which may help to curb disease transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.