Evidence map›Paper›PMID 33292560›Full record

ArticleDiabetology & metabolic syndrome2020

Increased leukotriene B4 plasma concentration in type 2 diabetes individuals with cardiovascular autonomic neuropathy.

Jose Antonio Januario Neves, Mozânia Reis De Matos, Theresa Ramalho, Daniele Pereira Santos-Bezerra, Cristiane Das Graças Dias Cavalcante, Renata D' Alpino Peixoto, Márcia Silva Queiroz, Sonia Jancar, Maria Lucia Correa-Giannella

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetology & metabolic syndrome, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jose Antonio Januario NevesPrograma de Pos-Graduação Em Medicina, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235, 2° subsolo, Pos-graduação, Sao Paulo, CEP: 01504-001, Brazil.
Mozânia Reis De MatosPrograma de Pos-Graduação Em Medicina, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235, 2° subsolo, Pos-graduação, Sao Paulo, CEP: 01504-001, Brazil.
Theresa RamalhoLaboratório de Imunofarmacologia, Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Prof. Lineu Prestes, 1730, Sao Paulo, CEP: 05508-900, Brazil.
Daniele Pereira Santos-BezerraLaboratório de Carboidratos E Radioimunoensaio (LIM-18) Do Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Avenida Dr. Arnaldo, 455, Sala 3321, Sao Paulo, CEP: 01246-903, Brazil.
Cristiane Das Graças Dias CavalcanteUnidade Básica de Saúde Dra. Ilza Weltman Hutzler. Rua Coronel Walfrido de Carvalho, Sao Paulo, CEP: 02472-180, Brazil.
Renata D' Alpino PeixotoPrograma de Pos-Graduação Em Medicina, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235, 2° subsolo, Pos-graduação, Sao Paulo, CEP: 01504-001, Brazil.
Márcia Silva QueirozPrograma de Pos-Graduação Em Medicina, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235, 2° subsolo, Pos-graduação, Sao Paulo, CEP: 01504-001, Brazil.
Sonia JancarLaboratório de Imunofarmacologia, Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Prof. Lineu Prestes, 1730, Sao Paulo, CEP: 05508-900, Brazil.
Maria Lucia Correa-GiannellaPrograma de Pos-Graduação Em Medicina, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235, 2° subsolo, Pos-graduação, Sao Paulo, CEP: 01504-001, Brazil. m.giannella@uni9.pro.br.ORCID http://orcid.org/0000-0003-3655-4446
Universidade Nove de Julho · BRUniversidade de São Paulo · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BR

Funding

FAPESP 2013/15719-0
6 · The paper itself

Abstract

BACKGROUND AND

aimA low-grade inflammation is associated with cardiac autonomic neuropathy (CAN) and increased concentration of leukotriene B4 (LTB4) was found in individuals with type 1 diabetes and definitive CAN. This cross-sectional study evaluated plasma concentration of LTB4 and of other inflammatory mediators, namely, tumor necrosis factor (TNF), interleukin (IL)1B, and IL10 in individuals with type 2 diabetes (T2D) and different degrees of CAN, and correlated these inflammatory mediators with the degree of glycemic control and with a surrogate marker of insulin resistance.

methodsTNF, IL1B, IL10 and LTB4 plasma concentrations were measured in 129 T2D subjects (62% women with [median] age of 63 years, disease duration of 8 years and HbA1c of 7.3%) with or without CAN. The Lipid accumulation product index was used as a surrogate marker of insulin resistance.

resultsLTB4 concentration was significantly higher in those presenting incipient CAN (69.7 ± 16.6 pg mL

conclusionIn the T2D setting, circulating LTB4 concentration seems to be associated with cardiovascular dysautonomia.

Indexed as

Chronic diabetes complicationsInflammationInsulin resistanceLTB4

Identifiers

PMID33292560
PMCPMC7663893
OpenAlexW3100862376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.