ReviewJournal of animal science and biotechnology2020
Neonatal lamb mortality: major risk factors and the potential ameliorative role of melatonin.
Review in Journal of animal science and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Does Melatonin Enhance Twin Lamb Survival in Commercial Merino Flocks in Australia?Animals : an open access journal from MDPI · 2025Article
- Pre and post weaning performance of Columbia sheep under an intensive system of the central Mexico: an alternative to enhance meat production.Tropical animal health and production · 2025Article
- Identifying Genetic Predisposition to Dozer Lamb Syndrome: A Semi-Lethal Muscle Weakness Disease in Sheep.Genes · 2025Article
- Maternal supplementation with melatonin during mid-pregnancy does not improve the survival of one-year-old ewes and their lambs.Journal of animal science · 2025Article
- Effects of grape seed extract supplementation on the growth performance, nutrients digestion and immunity of weaned lambs.Frontiers in veterinary science · 2024Article
- Herd health and reproductive management associated with lamb weight gain and mortality in sub-Saharan drylands-a case from Ethiopia.Tropical animal health and production · 2023Article
- Strategies and Mechanisms of Thermal Compensation in Newborn Water Buffaloes.Animals : an open access journal from MDPI · 2023Review
- A Trace Mineral Injection before Joining and Lambing Increases Marking Percentages and Lamb Weights on Diverse Farms in Victoria, Australia.Animals : an open access journal from MDPI · 2023Article
- The effect of birth weight and time of day on the thermal response of newborn water buffalo calves.Frontiers in veterinary science · 2023Article
- Colostrum traits and newborn body weight and growth: comparison between single and twin underfed sheep pregnancies.Frontiers in veterinary science · 2023Article
- A Nonsense Variant inGenes · 2021Article
- The Price of Surviving on Adrenaline: Developmental Programming Responses to Chronic Fetal Hypercatecholaminemia Contribute to Poor Muscle Growth Capacity and Metabolic Dysfunction in IUGR-Born Offspring.Frontiers in animal science · 2021Article
- Going Up Inflame: Reviewing the Underexplored Role of Inflammatory Programming in Stress-Induced Intrauterine Growth Restricted Livestock.Frontiers in animal science · 2021Article
- Perinatal complications and maximising lamb survival in an adolescent paradigm characterised by premature delivery and low birthweight.PloS one · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High incidences of pre-weaning mortality continue to limit global sheep production, constituting a major economic and welfare concern. Despite significant advances in genetics, nutrition, and management, the proportion of lamb deaths has remained stable at 15-20% over the past four decades. There is mounting evidence that melatonin can improve outcomes in compromised ovine pregnancies via enhanced uterine bloodflow and neonatal neuroprotection. This review provides an overview of the major risk factors and underlying mechanisms involved in perinatal lamb mortality and discusses the potential of melatonin treatment as a remedial strategy. Supplementing pregnant ewes with melatonin enhances uterine bloodflow and fetal oxygenation, and potentially birthweight and neonatal thermogenic capacity. Melatonin freely crosses the ovine placenta and blood-brain barrier and provides neuroprotection to the fetal lamb during periods of chronic and acute hypoxia throughout gestation, with improved behavioural outcomes in hypoxic neonates. The current literature provides strong evidence that maternal melatonin treatment improves outcomes for lambs which experience compromised in utero development or prolonged parturition, though to date this has not been investigated in livestock production systems. As such there is a clear basis for continued research into the effects of maternal melatonin supplementation during gestation on pre-weaning survival under extensive production conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.