ArticleClinical and translational allergy2020
Variation in IgE binding potencies of seven Artemisia species depending on content of major allergens.
Article in Clinical and translational allergy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Unraveling the increasing burden of allergies: Spatiotemporal dynamics of pollen allergy risk in China.Eco-Environment & Health · 2026Article
- [Epidemiological investigation and risk factors analysis of allergic rhinitis induced by Artemisia pollen in northern China].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026Article
- Art an 3 as a candidate recombinant antigen for Artemisia pollen immunotherapy: comparative efficacy and mechanistic insights.Frontiers in medicine · 2026Article
- [Pollen-food allergy syndrome: association between allergen cross-reactivity and symptom severity].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Article
- Developmental and quantitative expression profile of the six pollen allergens of mugwort (Artemisia vulgaris L.).BMC plant biology · 2025Article
- Allergic Potential of Medicinal Plants From the Asteraceae Family.Health science reports · 2025Article
- The role of major allergens Art v 1 and Art v 3 inFrontiers in immunology · 2025Article
- A secondAerobiologia · 2025Article
- Mugwort sensitization and asthma as predictors of food-induced anaphylactic shock in children: a retrospective study in Northern China.Frontiers in allergy · 2025Article
- Food-Pollen Cross-Reactivity and its Molecular Diagnosis in China.Current allergy and asthma reports · 2024Review
- Non-Specific Lipid Transfer Protein Amb a 6 Is a Source-Specific Important Allergenic Molecule in Ragweed Pollen.International journal of molecular sciences · 2024Article
- Allergenic Properties and Molecular Characteristics of PR-1 Proteins.Frontiers in allergy · 2022Review
- Peach allergen Pru p 1 content is generally low in fruit but with large variation in different varieties.Clinical and translational allergy · 2021Article
- Allergens of Regional Importance in Korea.Frontiers in allergy · 2021Review
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25 authors.
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Abstract
backgroundArtemisia weed pollen allergy is important in the northern hemisphere. While over 350 species of this genus have been recorded, there has been no full investigation into whether different species may affect the allergen diagnosis and treatment. This study aimed to evaluate the variations in amino acid sequences and the content of major allergens, and how these affect specific IgE binding capacity in representative Artemisia species.
methodsSix representative Artemisia species from China and Artemisia vulgaris from Europe were used to determine allergen amino acid sequences by transcriptome, gene sequencing and mass spectrometry of the purified allergen component proteins. Sandwich ELISAs were developed and applied for Art v 1, Art v 2 and Art v 3 allergen quantification in different species. Aqueous pollen extracts and purified allergen components were used to assess IgE binding by ELISA and ImmunoCAP with mugwort allergic patient serum pools and individual sera from five areas in China.
resultsThe Art v 1 and Art v 2 homologous allergen sequences in the seven Artemisia species were highly conserved. Art v 3 type allergens in A. annua and A. sieversiana were more divergent compared to A. argyi and A. vulgaris. The allergen content of Art v 1 group in the seven extracts ranged from 3.4% to 7.1%, that of Art v 2 from 1.0% to 3.6%, and Art v 3 from 0.3% to 10.5%. The highest IgE binding potency for most Chinese Artemisia allergy patients was with A. annua pollen extract, followed by A. vulgaris and A. argyi, with A. sieversiana significantly lower. Natural Art v 1-3 isoallergens from different species have almost equivalent IgE binding capacity in Artemisia allergic patients from China. CONCLUSION AND CLINICAL RELEVANCE: There was high sequence similarity but different content of the three group allergens from different Artemisia species. Choice of Artemisia annua and A. argyi pollen source for diagnosis and immunotherapy is recommended in China.
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