Evidence map›Paper›PMID 33292494›Full record

ArticleArchives of public health = Archives belges de sante publique2020

Why did EFSA not reduce its ADI for aspartame or recommend its use should no longer be permitted?

Erik Paul Millstone, Elisabeth Dawson

Abstract readLetter
In one paragraph

Article in Archives of public health = Archives belges de sante publique, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Erik Paul MillstoneSPRU - Science Policy Research Unit, Freeman Centre, Jubilee Building, University of Sussex, Brighton, BN1 9SL, England. e.p.millstone@sussex.ac.uk.ORCID http://orcid.org/0000-0001-9034-0567
Elisabeth DawsonSPRU - Science Policy Research Unit, Freeman Centre, Jubilee Building, University of Sussex, Brighton, BN1 9SL, England.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

On behalf of the European Food Safety Authority (EFSA), Kass and Lodi recently published a letter purporting to 'refute' our July 2019 analysis of EFSA's December 2013 assessment of the risks of aspartame. We had previously claimed inter alia that the EFSA panel had evaluated studies that had indicated that aspartame might be harmful far more sceptically than those that had not indicated harm. We reported that EFSA had deemed every one of 73 studies suggesting harm to have been unreliable. Kass and Lodi provided a tabulation with figures that differed from ours in every detail. This commentary shows that, while Kass and Lodi provided a response to our analysis, they have not come close to refuting it. Our analysis provided detailed characterisations of each of the studies and how the panel interpreted them, but Kass and Lodi provide no corresponding information at all. Kass and Lodi claim that EFSA deemed 21 of 35 studies that had indicated possible harm to have been reliable. But if that is so, we now ask: why did the EFSA panel not recommend that aspartame should be banned, or at least tightly restricted?

Indexed as

AspartameEuropean food safety authorityRebuttalRisk assessment

Identifiers

PMID33292494
PMCPMC7654000

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.