Evidence map›Paper›PMID 33292468›Full record

ArticleChild and adolescent psychiatry and mental health2020

Socio-emotional and adaptive behaviour in children treated for severe anaemia at Lira Regional Referral Hospital, Uganda: a prospective cohort study.

Andrew Sentoogo Ssemata, Robert Opika Opoka, John Mbaziira Ssenkusu, Noeline Nakasujja, Chandy C John, Paul Bangirana

Open access · goldAbstract read
In one paragraph

Article in Child and adolescent psychiatry and mental health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Andrew Sentoogo SsemataDepartment of Psychiatry, Makerere University, College of Health Sciences, P.O. Box 7072, Kampala, Uganda. andrewssemata@yahoo.co.uk.ORCID http://orcid.org/0000-0003-0060-0842
Robert Opika OpokaDepartment of Paediatrics and Child Health, Makerere University, College of Health Sciences, Kampala, Uganda.
John Mbaziira SsenkusuDepartment of Epidemiology and Biostatistics, Makerere University, College of Health Sciences, Kampala, Uganda.
Noeline NakasujjaDepartment of Psychiatry, Makerere University, College of Health Sciences, P.O. Box 7072, Kampala, Uganda.
Chandy C JohnRyan White Center for Pediatric Infectious Disease & Global Health, School of Medicine, Indiana University, Indianapolis, IN, USA.
Paul BangiranaDepartment of Psychiatry, Makerere University, College of Health Sciences, P.O. Box 7072, Kampala, Uganda.
Makerere University · UGIndiana University – Purdue University Indianapolis · US

Funding

Severe Malaria And Risk to The Brain (SMART Brain)R01NS055349 · NINDS · UNIVERSITY OF MINNESOTA · PI Chandy C. John, Ruth Namazzi · 2008 to 2026
$11.2M
Research training in infection, nutrition and neurodevelopment in UgandaD43TW010928 · FIC · INDIANA UNIVERSITY INDIANAPOLIS · PI Chandy C. John · 2018 to 2026
$1.9M
Research Training in Infection and Neurodevelopment in UgandaD43NS078280 · NINDS · UNIVERSITY OF MINNESOTA · PI JOHN, CHANDY C. · 2011 to 2015
$1.1M
Acute vs. delayed iron therapy: effect on iron status, anemia and cognitionU01HD064698 · NICHD · UNIVERSITY OF MINNESOTA · PI JOHN, CHANDY C. · 2009 to 2013
$916k
FIC NIH HHS D43 TW010928National Institutes of Health (US) D43NS0708280NICHD NIH HHS U01 HD064698NINDS NIH HHS D43 NS078280NINDS NIH HHS R01 NS055349
6 · The paper itself

Abstract

backgroundSevere anaemia is a global public health challenge commonly associated with morbidity and mortality among children < 5 years of age in Sub-Saharan Africa. However, less is known about the behavioural performance of children < 5 years surviving severe anaemia in low resource settings. We investigated social-emotional and adaptive behaviour in children < 5 years diagnosed with severe anaemia in Northern Uganda.

methodsWe conducted a hospital based prospective cohort study among children 6-42 months who were treated for severe anaemia (n = 171) at Lira Regional Referral Hospital, Uganda. Socio-emotional and adaptive behaviour were assessed 14 days post discharge using the Bayley Scales of Infant and Toddler Development, 3rd edition. Age-adjusted z-scores for each domain were calculated using scores from healthy community children (n = 88) from the same environment for each age category. Multiple linear regression was used to compare z-scores in the social-emotional and adaptive behaviour scales between the two groups after adjusting for weight-for-age z-score, social economic status, mother's education, father's education and father's employment on all the scales.

resultsCompared with healthy community controls, children with severe anaemia had poorer [adjusted mean scores (standard error)], socio-emotional [- 0.29, (0.05) vs. 0.01, (0.08), P = 0.002]; but not overall/ composite adaptive behaviour [- 0.10, (0.05) vs. - 0.01, (0.07), P = 0.343]. Within the adaptive behaviour subscales, children with SA displayed significantly poorer scores on the community use [adjusted mean score (standard error)], [- 0.63, (0.10) vs. - 0.01, (0.13), P < 0.001]; and leisure [- 0.35, (0.07) vs. - 0.02, (0.07), P = 0.036] skills.

conclusionThis study suggests that severe anaemia in children < 5 years is associated with poor social-emotional scores in the short-term post clinical recovery in Northern Uganda. We recommend long-term follow-up to determine the course of these problems and appropriate interventions to reduce the behavioural burden among children < 5 years surviving severe anaemia in Uganda.

Indexed as

Adaptive behaviourChildrenNeurodevelopmentPre-schoolSevere anaemiaSocio-emotionalUganda

Identifiers

PMID33292468
PMCPMC7694894
OpenAlexW3109313583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.