Evidence map›Paper›PMID 33292444›Full record

ArticleGut pathogens2020

The absence of murine cathelicidin-related antimicrobial peptide impacts host responses enhancing Salmonella enterica serovar Typhimurium infection.

Danisa M Bescucci, Sandra T Clarke, Catherine L J Brown, Valerie F Boras, Tony Montina, Richard R E Uwiera, G Douglas Inglis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut pathogens, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. CommensalAnimals : an open access journal from MDPI · 2023
    Article
  3. Article
  4. Infection byPathogens (Basel, Switzerland) · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Danisa M BescucciLethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, AB, Canada.
Sandra T ClarkeLethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, AB, Canada.
Catherine L J BrownLethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, AB, Canada.
Valerie F BorasChinook Regional Hospital, Alberta Health Services, Lethbridge, AB, Canada.
Tony MontinaDepartment of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, AB, Canada.
Richard R E UwieraDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada.
G Douglas InglisLethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, AB, Canada. Douglas.Inglis@canada.ca.ORCID http://orcid.org/0000-0003-1769-7863
Agriculture and Agri-Food Canada · CAUniversity of Lethbridge · CAAlberta Health Services · CAUniversity of Alberta · CA

Funding

Agriculture and Agri-Food Canda 1613Alberta Livestock and Meat Agency 2015B008RAlberta Livestock and Meat Agency 2016E002Canadian Glycomics Network CD-30Canadian Glycomics Network CD-60
6 · The paper itself

Abstract

backgroundCathelicidins are a class of antimicrobial peptide, and the murine cathelicidin-related antimicrobial peptide (mCRAMP) has been demonstrated in vitro to impair Salmonella enterica serovar Typhimurium proliferation. However, the impact of mCRAMP on host responses and the microbiota following S. Typhimurium infection has not been determined. In this study mCRAMP

resultsHigher densities of the pathogen were observed in cecal digesta and associated with mucosa in SA+/mCRAMP

conclusionThe study findings showed that the absence of mCRAMP modulated both host responses and the enteric microbiota enhancing local and systemic infection by Salmonella Typhimurium.

Indexed as

CathelicidinColonization resistancemCRAMPMiceMicrobiotaSalmonella enterica Typhimurium

Identifiers

PMID33292444
PMCPMC7666523
OpenAlexW3104115381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.