Evidence map›Paper›PMID 33292305›Full record

ArticleNutrition & metabolism2020

Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a Chinese population-based study.

Zhe Wang, Aimin Yang, Jing Yang, Weihong Zhao, Zhilian Wang, Wei Wang, Jintao Wang, Jinghui Song, Li Li, Weiguo Lv and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition & metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Vitamin K and women's health: a review.Frontiers in global women's health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Zhe WangDepartment of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, 382 Wuyi Rd, Taiyuan, 030001, Shanxi, China.
Aimin YangHong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR.
Jing YangDepartment of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, 382 Wuyi Rd, Taiyuan, 030001, Shanxi, China.
Weihong ZhaoDepartment of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, 382 Wuyi Rd, Taiyuan, 030001, Shanxi, China.
Zhilian WangDepartment of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, 382 Wuyi Rd, Taiyuan, 030001, Shanxi, China.
Wei WangDepartment of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, 382 Wuyi Rd, Taiyuan, 030001, Shanxi, China.
Jintao WangDepartment of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan, China.
Jinghui SongDepartment of Obstetrics and Gynecology, Affiliated Hospital of Inner Mongolia Medical University, Huhhot, China.
Li LiDepartment of Obstetrics and Gynecology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.
Weiguo LvDepartment of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Dongyan LiDepartment of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, 382 Wuyi Rd, Taiyuan, 030001, Shanxi, China.
Huiqiang LiuDepartment of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, 382 Wuyi Rd, Taiyuan, 030001, Shanxi, China.
Chen WangDepartment of Pathology, Second Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Min HaoDepartment of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, 382 Wuyi Rd, Taiyuan, 030001, Shanxi, China. 2yuanhaomin@163.com.
Shanxi Medical University · CNSecond Hospital of Shanxi Medical University · CNChinese University of Hong Kong · CNInner Mongolia Medical University · CNWomen's Hospital, School of Medicine, Zhejiang University · CN

Funding

Key research and development project of Shanxi province 201803D31121National Natural Science Foundation of China 81972452Shanxi provincial Health Planning Commission 2018GW04Special Public Welfare Industry Research of National Health and Family Planning Commission of China 201402010the applied basic research project of Shanxi province 201601D011086
6 · The paper itself

Abstract

backgroundDietary nutrient intake plays a significant role in carcinogenesis. Few studies have investigated the association between dietary nutrient intake and cervical intraepithelial neoplasia (CIN) risk in China.

methodsData on 2304 women from an ongoing cohort comprising 40,000 women from China in 2014 were included. Study randomly selected 218 out of 2304 people as subjects during 2019. All participants were surveyed through in-person interviews, physical examinations, and laboratory tests. Clinical data were obtained from physical examinations and laboratory tests. Dietary intakes were assessed using a semiquantitative food frequency questionnaire. Nutrition intakes from 26 food sources were calculated using a comprehensive validated database. Descriptive statistics were used to describe the frequency and proportion, and mean and standard deviation of the demographic characteristics. Characteristics were examined for significant differences, and Pearson chi-square tests were used for categoric variables. Logistic regression was used to obtain odds ratios (ORs) and confidence intervals (CIs) for CIN risk in each nutrient intake quartile relative to that in the highest quartile.

resultsThe food frequency questionnaire exhibited acceptable reproducibility and reasonable validity in assessing nutrient intakes among these women. After adjusting for multiple confounders, several dietary nutrients showed significant associations with CIN2+ risk. Low dietary folate intake was associated with the risk of CIN2+ (first versus fourth quartile: OR = 1.55, 95% CI 1.03-2.33). Similar results were also observed for vitamin B6 (OR = 1.63, 95% CI 1.08-2.46), vitamin C (OR = 1.59, 95% CI 1.05-2.42), niacin (OR = 1.65, 95% CI 1.08-2.51), and vitamin K (second versus fourth quartile: OR = 1.60, 95% CI 1.05-2.44).

conclusionsLow folate; vitamin B6, C, and K; and niacin intakes were associated with CIN2+ risk. Nutrients may influence the development of higher grade CIN and cervical cancer. Trial registration The study was registered in the Chinese Clinical Trial Register (ChiCTR-ROC-15006479) ( https://www.chictr.org.cn ).

Indexed as

Cervical intraepithelial neoplasiaChinaCross-sectional analysisNutrient intakeVitamin

Identifiers

PMID33292305
PMCPMC7708219
OpenAlexW3110130931

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.