Evidence map›Paper›PMID 33291798›Full record

ReviewInternational journal of molecular sciences2020

Toxicology and Analysis of Psychoactive Tryptamines.

Sara Malaca, Alfredo Fabrizio Lo Faro, Alice Tamborra, Simona Pichini, Francesco Paolo Busardò, Marilyn A Huestis

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Synthetic Cathinones and Neurotoxicity Risks: A Systematic Review.International journal of molecular sciences · 2023
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Total Syntheses of Deuterated Drugs: A Comprehensive Review.Topics in current chemistry (Cham) · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Perioperative considerations for patients exposed to hallucinogens.Regional anesthesia and pain medicine · 2024
    Review
  10. Article
  11. Article
  12. Pharmacologic Activity of Substituted Tryptamines at 5-Hydroxytryptamine (5-HT)The Journal of pharmacology and experimental therapeutics · 2023
    Article
  13. Review
  14. Article
  15. Human Hepatocyte 4-Acetoxy-Metabolites · 2022
    Article
  16. An Update on the Implications of New Psychoactive Substances in Public Health.International journal of environmental research and public health · 2022
    Review
  17. Review
  18. Molecular Insights on New Psychoactive Substances (NPSs).International journal of molecular sciences · 2022
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Sara MalacaDepartment of Excellence of Biomedical Sciences and Public Health, University "Politecnica delle Marche" of Ancona, Via Tronto 10, 60126 Ancona, Italy.
Alfredo Fabrizio Lo FaroDepartment of Excellence of Biomedical Sciences and Public Health, University "Politecnica delle Marche" of Ancona, Via Tronto 10, 60126 Ancona, Italy.
Alice TamborraDepartment of Excellence of Biomedical Sciences and Public Health, University "Politecnica delle Marche" of Ancona, Via Tronto 10, 60126 Ancona, Italy.
Simona PichiniNational Centre on Addiction and Doping, Istituto Superiore di Sanità, V.Le Regina Elena 299, 00161 Rome, Italy.
Francesco Paolo BusardòDepartment of Excellence of Biomedical Sciences and Public Health, University "Politecnica delle Marche" of Ancona, Via Tronto 10, 60126 Ancona, Italy.
Marilyn A HuestisInstitute of Emerging Health Professions, Thomas Jefferson University, 1020 Walnut St, Philadelphia, PA 19144, USA.ORCID 0000-0003-2137-4645
Marche Polytechnic University · ITIstituto Superiore di Sanità · ITThomas Jefferson University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our understanding of tryptamines is poor due to the lack of data globally. Tryptamines currently are not part of typical toxicology testing regimens and their contribution to drug overdoses may be underestimated. Although their prevalence was low, it is increasing. There are few published data on the many new compounds, their mechanisms of action, onset and duration of action, toxicity, signs and symptoms of intoxication and analytical methods to identify tryptamines and their metabolites. We review the published literature and worldwide databases to describe the newest tryptamines, their toxicology, chemical structures and reported overdose cases. Tryptamines are 5-HT

Indexed as

AnimalsChemistry Techniques, SyntheticChromatography, LiquidHumansMolecular StructurePsychotropic DrugsReproducibility of ResultsSensitivity and SpecificityTandem Mass SpectrometryToxicity TestsTryptaminesPsychotropic DrugsTryptaminesanalytical methodsnew psychoactive substances (NPS)psychedelicstoxicologytryptamines

Identifiers

PMID33291798
PMCPMC7730282
OpenAlexW3106917591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.