Evidence map›Paper›PMID 33291656›Full record

ArticleInternational journal of molecular sciences2020

Phorbol 12-Myristate 13-Acetate Induced Toxicity Study and the Role of Tangeretin in Abrogating HIF-1α-NF-κB Crosstalk In Vitro and In Vivo.

Sukkum Ngullie Chang, Debasish Kumar Dey, Seong Taek Oh, Won Ho Kong, Kiu Hyung Cho, Ebtesam M Al-Olayan, Buyng Su Hwang, Sun Chul Kang, Jae Gyu Park

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
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  8. Anti-Inflammatory Effects of Extracellular Vesicles fromInternational journal of molecular sciences · 2024
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  14. A Combination of Polymethoxyflavones fromAntioxidants (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Sukkum Ngullie ChangDepartment of Biotechnology, Daegu University, Gyeongsan 38453, Korea.
Debasish Kumar DeyDepartment of Biotechnology, Daegu University, Gyeongsan 38453, Korea.
Seong Taek OhAdvanced Bio Convergence Center, Pohang Technopark Foundation, Pohang 37668, Gyeongbuk, Korea.
Won Ho KongAdvanced Bio Convergence Center, Pohang Technopark Foundation, Pohang 37668, Gyeongbuk, Korea.
Kiu Hyung ChoResearch Group, Gyeongbuk Institute for Bio Industry (GIB), Andong 36728, Korea.
Ebtesam M Al-OlayanDepartment of Zoology, Faculty of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Buyng Su HwangNakdonggang National Institute of Biological Resources, Sangju 37242, Korea.ORCID 0000-0002-6774-7294
Sun Chul KangDepartment of Biotechnology, Daegu University, Gyeongsan 38453, Korea.
Jae Gyu ParkAdvanced Bio Convergence Center, Pohang Technopark Foundation, Pohang 37668, Gyeongbuk, Korea.ORCID 0000-0001-6757-0241
Pohang TechnoPark (South Korea) · KRDaegu University · KRGyeongbuk Marine Bio-Industry Research Institute · KRKing Saud University · SANational Institute of Biological Resources · KR

Funding

Department of Bio Life Industry "Nature & amp; Life Industry Technology Development Project" Grant 2018
6 · The paper itself

Abstract

Phorbol 12-myristate 13-acetate (PMA) is a potent tumor promoter and highly inflammatory in nature. Here, we investigated the toxic effects of PMA on different model system. PMA (10 μg) caused chromosomal aberrations on the

Indexed as

AnimalsAntioxidantsBiomarkersCell Line, TransformedCongenital AbnormalitiesEmbryonic DevelopmentEpidermisFlavonesHumansHypoxia-Inducible Factor 1, alpha SubunitInflammationKeratinocytesLipid PeroxidationNF-kappa BOnionsOxidative StressAntioxidantsBiomarkersFlavonesHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitNF-kappa BReactive Oxygen SpeciestangeretinTetradecanoylphorbol Acetateallium cepa testhypoxia-inducible factor 1-alpha (HIF-1α)inflammationnuclear factor kappa-light-chain-enhancer of activated b cells (NF-κb)phorbol 12-myristate 13-acetate (PMA)tangeretin (TAN)zebrafish embryotoxicity test

Identifiers

PMID33291656
PMCPMC7729754
OpenAlexW3107412563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.