Evidence map›Paper›PMID 33291525›Full record

ArticleJournal of functional biomaterials2020

Nanostructured Carbonated Hydroxyapatite Associated to rhBMP-2 Improves Bone Repair in Rat Calvaria.

Thiago Schneider Werner Vianna, Suelen Cristina Sartoretto, Adriana Terezinha Neves Novellino Alves, Rodrigo Figueiredo de Brito Resende, Carlos Fernando de Almeida Barros Mourão, Jose de Albuquerque Calasans-Maia, Victor R Martinez-Zelaya, Alexandre Malta Rossi, Jose Mauro Granjeiro, Monica Diuana Calasans-Maia and 1 more

Abstract read
In one paragraph

Article in Journal of functional biomaterials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Recent Developments in Polymer Nanocomposites for Bone Regeneration.International journal of molecular sciences · 2023
    Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Thiago Schneider Werner ViannaPos-Graduation Program, Dentistry School, Universidade Federal Fluminense, Rio de Janeiro 24020-140, Brazil.
Suelen Cristina SartorettoOral Surgery Department, Universidade Veiga de Almeida, Rio de Janeiro 20271-020, Brazil.ORCID 0000-0002-8414-3775
Adriana Terezinha Neves Novellino AlvesOral Diagnosis Department, Dentistry School, Universidade Federal Fluminense, Rio de Janeiro 24020-140, Brazil.
Rodrigo Figueiredo de Brito ResendeOral Surgery Department, Universidade Iguaçu, Rio de Janeiro 26260-045, Brazil.
Carlos Fernando de Almeida Barros MourãoPos-Graduation Program, Dentistry School, Universidade Federal Fluminense, Rio de Janeiro 24020-140, Brazil.ORCID 0000-0001-5775-0222
Jose de Albuquerque Calasans-MaiaOrthodontic Department, Dentistry School, Universidade Federal Fluminense, Rio de Janeiro 24020-140, Brazil.ORCID 0000-0002-1498-726X
Victor R Martinez-ZelayaBrazilian Synchrotron Light Laboratory (LNLS), Brazilian Center for Research in Energy and Materials (CNPEM), São Paulo 13083-970, Brazil.ORCID 0000-0001-5256-2919
Alexandre Malta RossiDepartment of Condensed Matter, Applied Physics and Nanoscience, Brazilian Center for Research in Physics, Rio de Janeiro 22290-180, Brazil.
Jose Mauro GranjeiroPos-Graduation Program, Dentistry School, Universidade Federal Fluminense, Rio de Janeiro 24020-140, Brazil.ORCID 0000-0002-8027-8293
Monica Diuana Calasans-MaiaOral Surgery Department, Dentistry School, Universidade Federal Fluminense, Rio de Janeiro 24020-140, Brazil.ORCID 0000-0001-5759-7926
Rafael Seabra LouroOral Surgery Department, Dentistry School, Universidade Federal Fluminense, Rio de Janeiro 24020-140, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many biomaterials are used for Bone Morphogenetic Proteins (BMPs) delivery in bone tissue engineering. The BMP carrier system's primary function is to hold these growth factors at the wound's site for a prolonged time and provide initial support for cells to attach and elaborate the extracellular matrix for bone regeneration. This study aimed to evaluate the nanostructured carbonated hydroxyapatite microspheres (nCHA) as an rhBMP-2 carrier on rats calvaria. A total of fifteen male Wistar rats were randomly divided into three groups (

Indexed as

bone regenerationcritical-size defectnanostructured carbonated hydroxyapatiterhBMP-2

Identifiers

PMID33291525
PMCPMC7768361

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.