ArticleCancers2020
Mapping the Relative Biological Effectiveness of Proton, Helium and Carbon Ions with High-Throughput Techniques.
Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- A standardized measurement-based approach to estimate modelled relative biological effectiveness for auditing carbon ion beams.Physics and imaging in radiation oncology · 2026Article
- Comparison of experimental and radiobiological model-predicted survival of human laryngeal squamous cell carcinoma cells in a helium spread-out Bragg peak.Physics and imaging in radiation oncology · 2026Article
- DNA damage complexity as a predictor of cell survival: a microscopic Monte Carlo-based modeling framework for photon, proton and carbon ion irradiation.Physics in medicine and biology · 2026Article
- Neural network modelling of proton RBE values at predominant survival fractions of in vitro data.Scientific reports · 2026Article
- Investigation of relative biological effectiveness for protons, carbon and oxygen ion beams by DNA damage calculations in a fractal fibroblast cell geometry.Radiological physics and technology · 2026Article
- Development and Validation of an Interface Between the BIANCA Biophysical Model and Geant4 for Particle Therapy.Biomedicines · 2026Article
- Microdosimetric characterization of proton relative biological effectiveness in pancreatic ductal adenocarcinoma cell lines.Frontiers in oncology · 2026Article
- Quantifying Sensitivity of Carbon RBE Models to Reference Parameter Variations.Radiation research · 2025Article
- Out-of-field neutron radiation from clinical proton, helium, carbon, and oxygen ion beams.Medical physics · 2025Article
- 'Dirty dose'-based proton variable RBE models - performance assessment on in vitro data.Medical physics · 2025Article
- Mimicking large spot-scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform.Precision radiation oncology · 2024Article
- Interpreting the biological effects of protons as a function of physical quantity: linear energy transfer or microdosimetric lineal energy spectrum?Scientific reports · 2024Article
- Particle Beam Radiobiology Status and Challenges: A PTCOG Radiobiology Subcommittee Report.International journal of particle therapy · 2024Review
- A time-resolved clonogenic assay for improved cell survival and RBE measurements.Clinical and translational radiation oncology · 2023Article
- Modeling RBE with other quantities than LET significantly improves prediction of in vitro cell survival for proton therapy.Medical physics · 2023Article
- Charged Particle and Conventional Radiotherapy: Current Implications as Partner for Immunotherapy.Cancers · 2021Review
- Radiotherapy in the Management of Pediatric and Adult Osteosarcomas: A Multi-Institutional Cohort Analysis.Cells · 2021Article
- Evaluation of Histone Deacetylase Inhibitors as Radiosensitizers for Proton and Light Ion Radiotherapy.Frontiers in oncology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
Large amounts of high quality biophysical data are needed to improve current biological effects models but such data are lacking and difficult to obtain. The present study aimed to more efficiently measure the spatial distribution of relative biological effectiveness (RBE) of charged particle beams using a novel high-accuracy and high-throughput experimental platform. Clonogenic survival was selected as the biological endpoint for two lung cancer cell lines, H460 and H1437, irradiated with protons, carbon, and helium ions. Ion-specific multi-step microplate holders were fabricated such that each column of a 96-well microplate is spatially situated at a different location along a particle beam path. Dose, dose-averaged linear energy transfer (LET
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.