Evidence map›Paper›PMID 33291470›Full record

ArticleDiagnostics (Basel, Switzerland)2020

High-Density Mineralized Protrusions and Central Osteophytes: Associated Osteochondral Junction Abnormalities in Osteoarthritis.

Alecio F Lombardi, Qingbo Tang, Jonathan H Wong, Judith L Williams, Saeed Jerban, Yajun Ma, Hyungseok Jang, Jiang Du, Eric Y Chang

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Interpretation of Cartilage Damage at Routine Clinical MRI: How to Match Arthroscopic Findings.Radiographics : a review publication of the Radiological Society of North America, Inc
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Alecio F LombardiResearch Service, VA San Diego Healthcare System, San Diego, CA 92161, USA.ORCID 0000-0002-6820-1779
Qingbo TangResearch Service, VA San Diego Healthcare System, San Diego, CA 92161, USA.
Jonathan H WongResearch Service, VA San Diego Healthcare System, San Diego, CA 92161, USA.
Judith L WilliamsResearch Service, VA San Diego Healthcare System, San Diego, CA 92161, USA.
Saeed JerbanResearch Service, VA San Diego Healthcare System, San Diego, CA 92161, USA.
Yajun MaResearch Service, VA San Diego Healthcare System, San Diego, CA 92161, USA.
Hyungseok JangResearch Service, VA San Diego Healthcare System, San Diego, CA 92161, USA.
Jiang DuResearch Service, VA San Diego Healthcare System, San Diego, CA 92161, USA.
Eric Y ChangResearch Service, VA San Diego Healthcare System, San Diego, CA 92161, USA.ORCID 0000-0003-3633-5630
University of California San Diego · USVA San Diego Healthcare System · US

Funding

Quantitative UTE MR Imaging: Sensitive Biomarkers for OsteoarthritisR01AR062581 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DU, JIANG · 2013 to 2022
$4.1M
Three-dimensional Ultrashort Echo Time Magnetic Resonance Imaging of EnthesesR01AR075825 · NIAMS · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI CHANG, ERIC Y · 2019 to 2023
$1.8M
Three-Dimensional UTE Magnetic Resonance Imaging of the Osteochondral JunctionR21AR075851 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MA, YAJUN · 2020 to 2021
$376k
Ultrashort Echo Time Magnetic Resonance Imaging of Bone Stress InjuriesR21AR073496 · NIAMS · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI CHANG, ERIC Y · 2018 to 2019
$343k
Quantitative Measurement of Joint pH with Magnetic Resonance ImagingI01RX002604 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI CHANG, ERIC Y · 2018 to 2022
–
NIAMS NIH HHS R01 AR062581NIAMS NIH HHS R01 AR075825NIAMS NIH HHS R21 AR073496NIAMS NIH HHS R21 AR075851RRD VA I01 RX002604
6 · The paper itself

Abstract

The aim of this study was to determine the association between high-density mineralized protrusions (HDMPs) and central osteophytes (COs), and describe the varying appearance of these lesions using advanced clinical imaging and a novel histological protocol. Seventeen consecutive patients with clinically advanced knee osteoarthritis undergoing knee arthroplasty were included. Surgical tissues containing the osteochondral region were investigated using computed tomography (CT); a subset was evaluated using confocal microscopy with fluorescence. Tissues from seven subjects (41.2%) contained HDMPs, and tissues from seven subjects (41.2%) contained COs. A significant association between HDMPs and COs was present (

Indexed as

central osteophytesHDMPosteoarthritisosteochondral junction

Identifiers

PMID33291470
PMCPMC7762145
OpenAlexW3112875929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.