Evidence map›Paper›PMID 33291465›Full record

ArticleInternational journal of molecular sciences2020

Proteomic Study Identifies Glycolytic and Inflammation Pathways Involved in Recurrent Otitis Media.

Blendi Ura, Fulvio Celsi, Luisa Zupin, Giorgio Arrigoni, Ilaria Battisti, Bartolomea Gaita, Domenico Leonardo Grasso, Eva Orzan, Raffaella Sagredini, Egidio Barbi and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Blendi UraInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", 65/1 Via dell'Istria, 34137 Trieste, Italy.
Fulvio CelsiInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", 65/1 Via dell'Istria, 34137 Trieste, Italy.ORCID 0000-0002-9760-8463
Luisa ZupinInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", 65/1 Via dell'Istria, 34137 Trieste, Italy.ORCID 0000-0001-5886-9129
Giorgio ArrigoniDepartment of Biomedical Sciences, University of Padova, Via U. Bassi 58/B, 35121 Padova, Italy.ORCID 0000-0002-4103-2733
Ilaria BattistiDepartment of Biomedical Sciences, University of Padova, Via U. Bassi 58/B, 35121 Padova, Italy.
Bartolomea GaitaInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", 65/1 Via dell'Istria, 34137 Trieste, Italy.ORCID 0000-0002-9690-0905
Domenico Leonardo GrassoInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", 65/1 Via dell'Istria, 34137 Trieste, Italy.
Eva OrzanInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", 65/1 Via dell'Istria, 34137 Trieste, Italy.ORCID 0000-0001-7465-1066
Raffaella SagrediniInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", 65/1 Via dell'Istria, 34137 Trieste, Italy.
Egidio BarbiInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", 65/1 Via dell'Istria, 34137 Trieste, Italy.ORCID 0000-0002-6343-846X
Sergio CrovellaDepartment of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University-Women's College of Sciences Building, Doha 2713, Qatar.ORCID 0000-0001-8493-1168
IRCCS Materno Infantile Burlo Garofolo · ITUniversity of Padua · ITQatar University · QAUniversity of Trieste · IT

Funding

Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste -Italy- RC 15/17 and RC 02/20
6 · The paper itself

Abstract

Recurrent acute otitis media (RAOM) in children is clinically defined as the occurrence of at least three episodes of acute otitis media over a course of 6 months. A further common pathological condition of interest in the context of pediatric otolaryngology is adenotonsillar hypertrophy (ATH), a common cause of obstructive sleep apnea syndrome. Aimed at unraveling the differential modulation of proteins in the two pathologies and at understanding the possible pathways involved in their onset, we analyzed the proteomic profile of the adenoids from 14 RAOM and ATH patients by using two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS). The 2-DE coupled with MS allowed us to identify 23 spots with significant (

Indexed as

ProteomeProteomicsDisease SusceptibilityElectrophoresis, Gel, Two-DimensionalGene Expression RegulationGlycolysisHumansMass SpectrometryMetabolic Networks and PathwaysOtitis MediaRecurrenceSignal TransductionProteome2-DEadenotonsillar hypertrophyproteomicsrecurrent otitis

Identifiers

PMID33291465
PMCPMC7731350
OpenAlexW3112074648

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.