Evidence map›Paper›PMID 33291444›Full record

ReviewToxins2020

Providing Antivenom Treatment Access to All Brazilian Amazon Indigenous Areas: 'Every Life Has Equal Value'.

Wuelton Marcelo Monteiro, Altair Seabra de Farias, Fernando Val, Alexandre Vilhena Silva Neto, André Sachett, Marcus Lacerda, Vanderson Sampaio, Deugles Cardoso, Luiza Garnelo, João Ricardo Nickenig Vissoci and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
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  5. Article
  6. Snakebite Envenomations In The Brazilian Amazon: A Little Less Neglected.Revista da Sociedade Brasileira de Medicina Tropical · 2026
    Review
  7. Article
  8. Article
  9. Article
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  11. Article
  12. SERPENT-Brasil: a technological tool for snakebite management.Revista panamericana de salud publica = Pan American journal of public health · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Wuelton Marcelo MonteiroDepartment of Medicine and Nursing, School of Health Sciences, Amazonas State University, Manaus 69065-001, Amazonas, Brazil.ORCID 0000-0002-0848-1940
Altair Seabra de FariasDepartment of Medicine and Nursing, School of Health Sciences, Amazonas State University, Manaus 69065-001, Amazonas, Brazil.
Fernando ValDepartment of Medicine and Nursing, School of Health Sciences, Amazonas State University, Manaus 69065-001, Amazonas, Brazil.ORCID 0000-0001-9995-0249
Alexandre Vilhena Silva NetoDepartment of Teaching and Research, Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus 69040-000, Amazonas, Brazil.
André SachettDepartment of Teaching and Research, Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus 69040-000, Amazonas, Brazil.
Marcus LacerdaDepartment of Teaching and Research, Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus 69040-000, Amazonas, Brazil.
Vanderson SampaioDepartment of Teaching and Research, Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus 69040-000, Amazonas, Brazil.ORCID 0000-0001-7307-8851
Deugles CardosoTechnical Department, Amazonas Health Surveillance Foundation, Manaus 69093-018, Amazonas, Brazil.
Luiza GarneloInstituto Leônidas & Maria Deane, Fiocruz, Manaus 69057-070, Amazonas, Brazil.
João Ricardo Nickenig VissociDivision of Emergency Medicine, Department of Surgery and Duke Global Health Institute, Duke University, Durham, NC 27710, USA.
Jacqueline SachettDepartment of Medicine and Nursing, School of Health Sciences, Amazonas State University, Manaus 69065-001, Amazonas, Brazil.
Fan Hui WenBioindustrial Centre, Butantan Institute, São Paulo 05503-900, São Paulo, Brazil.ORCID 0000-0002-8191-559X
Fundação de Medicina Tropical · BRDuke University · USInstituto Butantan · BRUniversidade do Estado do Amazonas · BR

Funding

Brazilian Ministry of Health 733781/19-035Fundação de Amparo à Pesquisa do Estado do Amazonas PAPAC 005/2019 PRO-ESTADO
6 · The paper itself

Abstract

Snakebites are more frequent in the Brazilian Amazon than in other parts of Brazil, representing a high cost for the health system since antivenoms are only available through medical prescription from central municipal hospitals in most cases. The need for a cold chain and physicians usually restricts access to the only effective treatment of a snakebite, the antivenom. The complex topography of the rivers contributes to delays in treatment, and consequently increases the risk of severe complications, chronic sequelae and death. Thus, decentralization of antivenom treatment to primary healthcare facilities in the interior would increase access by indigenous population groups to proper healthcare. To standardize and evaluate the decentralization to low complexity indigenous healthcare units, we suggest the (i) development and validation of standardized operational procedures, (ii) training of professionals in the validated protocol in a referral health unit, (iii) implementation of the protocol in an indigenous healthcare unit, (iv) assessment of perceptions towards and acceptability of the protocol, and (v) estimation of the impact of the protocol's implementation. We expect that antivenom decentralization would shorten the time between diagnosis and treatment and, as such, improve the prognosis of snakebites. As health cosmology among indigenous populations has an important role in maintaining their way of life, the introduction of a new therapeutic strategy to their customs must take into account the beliefs of these peoples. Thus, antivenom administration would be inserted as a crucial therapeutic tool in a world of diverse social, natural and supernatural representations. The information presented here also serves as a basis to advocate for support and promotion of health policy initiatives focused on evidence-based care in snakebite management.

Indexed as

Health Services AccessibilityAntiveninsBrazilHumansIndigenous PeoplesSnake BitesAntiveninsantivenomhealth decentralizationhealth serviceindigenous groupssnakebite

Identifiers

PMID33291444
PMCPMC7762137
OpenAlexW3111521781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.