Evidence map›Paper›PMID 33291428›Full record

ArticleMolecules (Basel, Switzerland)2020

Withanolide-Type Steroids from

Laila M Moujir, Gabriel G Llanos, Liliana Araujo, Angel Amesty, Isabel L Bazzocchi, Ignacio A Jiménez

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Withanolides Are Detected in Human Urine Following Oral Administration of aInternational journal of molecular sciences · 2026
    Article
  2. Review
  3. Identification of PotentialMetabolites · 2023
    Article
  4. Withanolide-Type Steroids fromJournal of natural products · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Laila M MoujirDepartment of Biochemistry, Microbiology, Cell Biology and Genetic, Faculty of Pharmacy, Universidad de La Laguna, Avenida Astrofisico Francisco Sánchez s/n, 38206 La Laguna, Spain.
Gabriel G LlanosInstitute of Bio-Orgánica Antonio González and Organic Chemistry Department, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.
Liliana AraujoDepartment of Biochemistry, Microbiology, Cell Biology and Genetic, Faculty of Pharmacy, Universidad de La Laguna, Avenida Astrofisico Francisco Sánchez s/n, 38206 La Laguna, Spain.
Angel AmestyInstitute of Bio-Orgánica Antonio González and Organic Chemistry Department, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.
Isabel L BazzocchiInstitute of Bio-Orgánica Antonio González and Organic Chemistry Department, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.ORCID 0000-0002-7698-2704
Ignacio A JiménezInstitute of Bio-Orgánica Antonio González and Organic Chemistry Department, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.ORCID 0000-0002-0641-607X
Universidad de La Laguna · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leukemia is a blood or bone marrow cancer with increasing incidence in developed regions of the world. Currently, there is an ongoing need for novel and safe anti-leukemic agents, as no fully effective chemotherapy is available to treat this life-threatening disease. Herein, are reported the isolation, structural elucidation, and anti-leukemic evaluation of twenty-nine withanolide-type steroids (

Indexed as

AnimalsAntineoplastic AgentsCell LineCell Line, TumorChlorocebus aethiopsHL-60 CellsHumansLeukemiaSteroidsStructure-Activity RelationshipVero CellsWithaniaWithanolidesAntineoplastic AgentsSteroidswithaferin AWithanolidesanti-leukemia activitydrug-likeness predictionstructure–activity relationshipWithania aristatawithasteroids

Identifiers

PMID33291428
PMCPMC7731379
OpenAlexW3110736143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.