ReviewJournal of clinical medicine2020
Uterine Fibroids and Progestogen Treatment: Lack of Evidence of Its Efficacy: A Review.
Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Prevalence and associated risk factors of uterine fibroids in the Kingdom of Eswatini.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2026Article
- Early Vascular and Morphological Response After Transvaginal Radiofrequency Ablation of Uterine Fibroids: A Doppler-Based Retrospective Study.Journal of clinical medicine · 2026Article
- Contemporary Management of Uterine Fibroids.Journal of clinical medicine · 2026Review
- The past, present and future of uterine fibroids.Facts, views & vision in ObGyn · 2026Article
- Psychosocial Stress and MicroRNA Expression Profiles in Myometrial Tissue of Women Undergoing Surgical Treatment for Uterine Fibroids.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- The efficacy of medical management of leiomyoma-associated heavy menstrual bleeding: a mini review.F&S reports · 2024Article
- Assessment of the Clinical Presentations and Ultrasonographic Features of Uterine Fibroids in Adult Africans: A Retrospective Study.Oman medical journal · 2023Article
- Possible significance of degeneration and decreased expression of progesterone receptor in postmenopausal uterine leiomyoma.BMC women's health · 2022Article
- Epigenomic and enhancer dysregulation in uterine leiomyomas.Human reproduction update · 2022Review
- Current approaches to overcome the side effects of GnRH analogs in the treatment of patients with uterine fibroids.Expert opinion on drug safety · 2022Review
- Historical Perspectives and Evolution of Menstrual Terminology.Frontiers in reproductive health · 2022Review
- Phytoprogestins: Unexplored Food Compounds with Potential Preventive and Therapeutic Effects in Female Diseases.Nutrients · 2021Review
- Conservative Management of Uterine Fibroid-Related Heavy Menstrual Bleeding and Infertility: Time for a Deeper Mechanistic Understanding and an Individualized Approach.Journal of clinical medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this review is to determine the evidence or, conversely, the absence of evidence regarding the effectiveness of progestogens in treating premenopausal women with uterine fibroids. In particular, the goal is to address recurring questions as to whether they are effective or not for managing symptoms commonly attributed to fibroids.
methodsA review of the most relevant papers (
resultsHaving reviewed the most significant papers on the relationship between uterine fibroids and progesterone/progestogens, it is clear that there is biochemical, histological and clinical evidence that progesterone and progestogens play a critical role in the pathogenesis of myomas.
conclusionSince progesterone is already implicated in the pathogenesis of this entity, using progestogens to manage fibroids is like constantly adding fuel to the fire, rendering this treatment ineffective.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.