Evidence map›Paper›PMID 33291384›Full record

ArticleGenes2020

The Association of Multiple Gene Variants with Ageing Skeletal Muscle Phenotypes in Elderly Women.

Praval Khanal, Lingxiao He, Adam J Herbert, Georgina K Stebbings, Gladys L Onambele-Pearson, Hans Degens, Christopher I Morse, Martine Thomis, Alun G Williams

Open access · goldAbstract read
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  3. TheMetabolites · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Praval KhanalMusculoskeletal Science and Sports Medicine Research Centre, Department of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester M15 6BH, UK.ORCID 0000-0003-2060-8446
Lingxiao HeMusculoskeletal Science and Sports Medicine Research Centre, Department of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester M15 6BH, UK.ORCID 0000-0002-2395-6035
Adam J HerbertDepartment of Sport and Exercise, Birmingham City University, Birmingham B5 5JU, UK.ORCID 0000-0001-8964-0087
Georgina K StebbingsMusculoskeletal Science and Sports Medicine Research Centre, Department of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester M15 6BH, UK.ORCID 0000-0003-0706-2864
Gladys L Onambele-PearsonMusculoskeletal Science and Sports Medicine Research Centre, Department of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester M15 6BH, UK.ORCID 0000-0002-1466-3265
Hans DegensDepartment of Life Sciences, Manchester Metropolitan University, Manchester M15 6BH, UK.ORCID 0000-0001-7399-4841
Christopher I MorseMusculoskeletal Science and Sports Medicine Research Centre, Department of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester M15 6BH, UK.ORCID 0000-0002-5261-2637
Martine ThomisDepartment of Movement Sciences, Physical Activity, Sports & Health Research Group, KU Leuven, 3001 Leuven, Belgium.ORCID 0000-0001-9093-2191
Alun G WilliamsMusculoskeletal Science and Sports Medicine Research Centre, Department of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester M15 6BH, UK.ORCID 0000-0002-8052-8184
Manchester Metropolitan University · GBBirmingham City University · GBKU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a scarcity of studies that have investigated the role of multiple single nucleotide polymorphisms (SNPs) on a range of muscle phenotypes in an elderly population. The present study investigated the possible association of 24 SNPs with skeletal muscle phenotypes in 307 elderly Caucasian women (aged 60-91 years, 66.3 ± 11.3 kg). Skeletal muscle phenotypes included biceps brachii thickness, vastus lateralis cross-sectional areas, maximal hand grip strength, isometric knee extension and elbow flexion torque. Genotyping for 24 SNPs, chosen on their skeletal muscle structural or functional links, was conducted on DNA extracted from blood or saliva. Of the 24 SNPs, 10 were associated with at least one skeletal muscle phenotype.

Indexed as

GenotypeHand StrengthMuscle, SkeletalPolymorphism, Single NucleotideAgedAged, 80 and overAgingFemaleHumansMiddle AgedMuscle ProteinsMuscle Proteinselderlygenotypingneuromuscularsingle nucleotide polymorphisms

Identifiers

PMID33291384
PMCPMC7762041
OpenAlexW3110206924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.