Evidence map›Paper›PMID 33291359›Full record

ArticleJournal of clinical medicine2020

Investigation of Basophil Activation Test for Diagnosing Milk and Egg Allergy in Younger Children.

Yoon Hee Kim, Young Suh Kim, Younhee Park, Soo Yeon Kim, Kyung Won Kim, Hyon Suk Kim, Myung Hyun Sohn

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06559319 (Evaluation Of the Basophil Activation Test in Child Egg Allergy Diagnosis), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06559319 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Evaluation Of the Basophil Activation Test in Child Egg Allergy Diagnosis

TypeobservationalSponsorXia PengRan2024 to 2027Enrolled174ConditionsFood AllergyArmsblood sampling
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. The Mechanism of Whey Protein Hydrolysates with Oral Immunotolerance.International journal of molecular sciences · 2026
    Article
  2. Casein sIgE avidity and milk basophil reactivity in children with cow's milk allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Basophils in atopic dermatitis: Immunologic roles and clinical implications.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026
    Review
  7. Article
  8. Article
  9. Basophil Activation Test Utility as a Diagnostic Tool in LTP Allergy.International journal of molecular sciences · 2022
    Article
  10. Article
  11. Practical challenges in oral immunotherapy resolved through patient-centered care.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021
    Review
  12. Biomarkers in oral immunotherapy.Journal of Zhejiang University. Science. B
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yoon Hee KimDepartment of Pediatrics, Institute of Allergy, Institute of Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea.
Young Suh KimDepartment of Pediatrics, Institute of Allergy, Institute of Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea.
Younhee ParkDepartment of Laboratory Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.
Soo Yeon KimDepartment of Pediatrics, Institute of Allergy, Institute of Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea.
Kyung Won KimDepartment of Pediatrics, Institute of Allergy, Institute of Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID 0000-0003-4529-6135
Hyon Suk KimDepartment of Laboratory Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID 0000-0001-5662-7740
Myung Hyun SohnDepartment of Pediatrics, Institute of Allergy, Institute of Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea.
Yonsei University · KR

Funding

National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT & Future Planning NRF-2020R1A2B5B02001713 and NRF-2018R1A5A2025079
6 · The paper itself

Abstract

In children with concomitant food allergy and atopic dermatitis (AD), uncovering the causative food allergen is more arduous. We evaluated the basophil activation test (BAT) for its diagnostic value in children, including those with AD, for milk or egg allergy. We simultaneously measured serum-specific immunoglobulin E (sIgE) levels and performed BATs for cow's milk and egg white. We compared their overall diagnostic performance using the area under the receiver operating characteristic curve (AUC) with the Delong method and compared them in children with AD. Analyses were completed for 75 children for milk allergy and for 85 children for egg allergy. The sIgE and percentage of basophils with the expression of CD63 were correlated for both milk (r = 0.384,

Indexed as

anaphylaxisatopic dermatitisbasophil activation testchilddiagnosisfood allergy

Identifiers

PMID33291359
PMCPMC7762017
OpenAlexW3108008586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.