Evidence map›Paper›PMID 33291273›Full record

ArticleJournal of clinical medicine2020

Incidence and Management of Hypertriglyceridemia-Associated Acute Pancreatitis: A Prospective Case Series in a Single Australian Tertiary Centre.

Hong Lin Evelyn Tan, Georgina McDonald, Alexander Payne, William Yu, Zahrul Ismadi, Huy Tran, Jon Gani, Katie Wynne

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hong Lin Evelyn TanDepartment of Diabetes & Endocrinology, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.
Georgina McDonaldSchool of Medicine & Public Health, University of Newcastle, New Lambton Heights, NSW 2305, Australia.
Alexander PayneDepartment of Medicine, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.
William YuDepartment of Medicine, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.
Zahrul IsmadiDepartment of Clinical Chemistry, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.
Huy TranSchool of Medicine & Public Health, University of Newcastle, New Lambton Heights, NSW 2305, Australia.
Jon GaniSchool of Medicine & Public Health, University of Newcastle, New Lambton Heights, NSW 2305, Australia.
Katie WynneDepartment of Diabetes & Endocrinology, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.ORCID 0000-0002-7980-3337
John Hunter Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypertriglyceridemia-associated acute pancreatitis (HTGAP) has been linked with increased severity and morbidity. In this study, triglyceride levels were measured in all patients admitted with acute pancreatitis (AP) to establish the incidence of HTGAP in an Australian center.

methodsA prospective cohort with AP was collated over an 18-month period in a single tertiary referral hospital. HTGAP was defined as AP with triglycerides ≥ 11.2 mmol/L (1000 mg/dL). Incidence, clinical co-morbidities, severity and management strategies were recorded.

resultsOf the 292 episodes of AP, 248 (85%) had triglycerides measured and were included. HTGAP was diagnosed in 10 of 248 (4%) AP cases. Type 2 diabetes, obesity, alcohol misuse and gallstones were common cofactors. The HTGAP group demonstrated severe hypertriglyceridemia compared to the non-HTGAP group (median 51 mmol/L vs. 1.3 mmol/L). Intensive care unit (ICU) admissions were significantly increased (odds ratio (OR) 16; 95% CI 4-62) in the HTGAP group (5/10 vs. 14/238 admissions,

conclusionHTGAP occurred in 4% of AP cases and was associated with higher risk of ICU admission. Intravenous insulin and fasting appear safe and efficacious for acutely lowering triglyceride levels in HTGAP.

Indexed as

acute pancreatitishypertriglyceridemiaintravenous insulin therapy

Identifiers

PMID33291273
PMCPMC7762124
OpenAlexW3111372757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.