Evidence map›Paper›PMID 33291255›Full record

ReviewInternational journal of molecular sciences2020

Cellular Consequences of Coenzyme Q10 Deficiency in Neurodegeneration of the Retina and Brain.

Haider Manzar, Dalia Abdulhussein, Timothy E Yap, M Francesca Cordeiro

Registry-linked trialAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06452134 (Evaluation the Effect of Coenzyme Q10 on Tissue Healing Process in Patients Undergoing Wisdom Tooth Extraction in the City of Sanandaj-Iran in 1402), which is not on this map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06452134 phase4unknown statusnot on this mapstarted 2024, after this paper: background citation

Evaluation the Effect of Coenzyme Q10 on Tissue Healing Process in Patients Undergoing Wisdom Tooth Extraction in the City of Sanandaj-Iran in 1402: a Double-blinded Clinical Trial Study

TypeinterventionalSponsorZahra NejatiRan2024 to 2025Enrolled70ConditionsMolar, Third, Temporomandibular Joint Disorders, Dry Socket, Coenzyme Q10ArmsCoenzyme Q10 100 MG Oral Tablet, Placebo
3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Coenzyme Q10 and Xenobiotic Metabolism: An Overview.International journal of molecular sciences · 2025
    Review
  9. Review
  10. Article
  11. A Pilot Trial of Nicotinamide Riboside and Coenzyme Q10 on Inflammation and Oxidative Stress in CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. The Scavenging Activity of Coenzyme QInternational journal of molecular sciences · 2024
    Article
  17. The Effect of Neuronal CoQInternational journal of molecular sciences · 2024
    Article
  18. Review
  19. CoQAntioxidants (Basel, Switzerland) · 2024
    Review
  20. Research Progress of Coenzyme Q in Diabetes Mellitus and Its Common Complications.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Haider ManzarImperial College Ophthalmology Research Group, Western Eye Hospital, 153-173 Marylebone Road, Marylebone, London NW1 5QH, UK.
Dalia AbdulhusseinImperial College Ophthalmology Research Group, Western Eye Hospital, 153-173 Marylebone Road, Marylebone, London NW1 5QH, UK.
Timothy E YapImperial College Ophthalmology Research Group, Western Eye Hospital, 153-173 Marylebone Road, Marylebone, London NW1 5QH, UK.
M Francesca CordeiroImperial College Ophthalmology Research Group, Western Eye Hospital, 153-173 Marylebone Road, Marylebone, London NW1 5QH, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coenzyme Q10 (CoQ10) is a ubiquitous cofactor in the body, operating in the inner mitochondrial membrane, where it plays a vital role in the generation of adenosine triphosphate (ATP) through the electron transport chain (ETC). In addition to this, CoQ10 serves as an antioxidant, protecting the cell from oxidative stress by reactive oxygen species (ROS) as well as maintaining a proton (H

Indexed as

AnimalsAtaxiaBrainHumansMitochondrial DiseasesMuscle WeaknessNeurodegenerative DiseasesRetinaUbiquinonecoenzyme Q10Ubiquinoneapoptosiscoenzyme Q10neurodegenerationreactive oxygen species

Identifiers

PMID33291255
PMCPMC7730520

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.