ArticleInternational journal of environmental research and public health2020
Levels of Gene Expression of Immunological Biomarkers in Peri-Implant and Periodontal Tissues.
Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of Vaping on Treatment Outcomes in Patients With Gingivitis, Periodontitis, and/or Peri-Implant Disease: A Systematic Review.Clinical and experimental dental research · 2026Pooled it
- Macrophage-induced immunomodulation in oral tissue repair and regeneration: Recent advances and future perspectives.Journal of advanced research · 2026Review
- Relationship between the miR-146a rs57095329 polymorphism and the risk of peri-implantitis.Journal of periodontal & implant science · 2026Article
- Peri-Implantitis and Periodontitis: Biological Convergence, Contextual Divergence.Journal of periodontal research · 2026Review
- Tannic acid-assisted mechanical training transforms natural hydrogels into robust and bioactive membranes for guided bone regeneration.Materials today. Bio · 2026Article
- Peri-Implant Crevicular Fluid Analysis by Mid-Infrared Spectroscopy in Peri-Implantitis-A Pilot Study.Clinical oral implants research · 2026Article
- Biomarker-Guided Implant Maintenance (BGIM): A Narrative Review and Protocol Proposal.Journal of clinical medicine · 2026Review
- Spatial Transcriptomic Assessments of Gene Expression Profiles in Human Peri-Implant Lesions.Journal of clinical periodontology · 2026Article
- Effect and mechanism of Sanqi () in treating periodontitis.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- A scoping review of diagnostic techniques used for the detection of peri-implantitis around endosseous dental implants.Frontiers in dental medicine · 2025Review
- The Association of Matrix Metalloproteinase-1, -2, -3, -7, and -13 Gene Polymorphisms With Peri-Implantitis in an Iranian Population: A Case-Control Study.Clinical and experimental dental research · 2024Article
- Expression of miRNAs (146a and 155) in human peri-implant tissue affected by peri-implantitis: a case control study.BMC oral health · 2024Article
- Immune dysregulation and macrophage polarization in peri-implantitis.Frontiers in bioengineering and biotechnology · 2024Review
- Expression of IL-1β, IL-6, TNF-α, and a-MMP-8 in sites with healthy conditions and with periodontal and peri-implant diseases: A case-control study.Journal of dental research, dental clinics, dental prospects · 2024Article
- Article
- Narrative Review of Biomarkers in Patients with Peri-implantitis : Biomarkers in Patients with Peri-implantitis.Galen medical journal · 2024Review
- Current Molecular, Cellular and Genetic Aspects of Peri-Implantitis Disease: A Narrative Review.Dentistry journal · 2023Review
- The relationship between matrix metalloproteinases-8 andThe Saudi dental journal · 2023Review
- Review
- Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study compared the gene expression of the immunoinflammatory markers interleukin (IL)-6, IL-1ß, and tumor necrosis factor alpha (TNF-α), the matrix metalloproteinases (MMP)-1, -2, -8, and -9, and the tissue inhibitors of matrix metalloproteases (TIMP)-1 and -2 in the gingival tissue of individuals with periodontal and peri-implant disease. The study population included individuals with four periodontal statuses: periodontal health (PH group, n = 20); periodontitis (P group, n = 20); peri-implant health (PIH group, n = 20), and peri-implantitis (PI group, n = 20). Gingival biopsies were collected from one tooth per patient according to the inclusion criteria of each group. The mRNA levels of IL-6, IL-1ß, TNF-α, MMP-1, MMP-2, MMP-8, MMP-9, TIMP-1, and TIMP-2 were evaluated by qPCR. The levels of IL-1ß were significantly higher in the PI group when compared to the other groups (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.