ArticleThe Journal of pediatrics2021
Kidney Outcomes and Hypertension in Survivors of Wilms Tumor: A Prospective Cohort Study.
Article in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Efficacy and late kidney effects of nephron-sparing surgery in the management of unilateral Wilms tumor: a systematic review and meta-analysis.Pediatric surgery international · 2023Pooled it
- Renal outcomes and compensatory hypertrophy in survivors of unilateral non-syndromic Wilms tumour: a single-centre cross-sectional study from a tertiary-care institution in India.Pediatric surgery international · 2026Article
- Predictors and course of hypertension in Wilms tumour patients: a retrospective observational cohort study.BMJ paediatrics open · 2025Observational
- Long-term kidney outcomes in survivors of Wilms tumor: a single-center retrospective cohort study.Pediatric nephrology (Berlin, Germany) · 2025Article
- Hypertension in Childhood Cancer Survivors: Causes, Screening, and Management.Current hypertension reports · 2025Review
- Kidney Function and Body Composition in Adult Survivors of Unilateral, Non-Syndromic Wilms Tumor: A Report From the St. Jude Lifetime Cohort Study.Pediatric blood & cancer · 2025Article
- Hypertension in Wilms tumor.Pediatric nephrology (Berlin, Germany) · 2024Review
- Masked Hypertension in Healthy Children and Adolescents: Who Should Be Screened?Current hypertension reports · 2023Review
- Long-Term Kidney and Cardiovascular Complications in Pediatric Cancer Survivors.The Journal of pediatrics · 2023Article
- Increased risk for kidney sequelae surrogates in survivors of Wilms tumor.Pediatric nephrology (Berlin, Germany) · 2022Article
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveTo assess the prevalence of therapy-related kidney outcomes in survivors of Wilms tumor (WT). STUDY
designThis prospective cohort study included survivors of WT who were ≥5 years old and ≥1 year from completing therapy, excluding those with preexisting hypertension, prior dialysis, or kidney transplant. Participants completed 24-hour ambulatory blood pressure monitoring (ABPM). Abnormal blood pressure (BP) was defined as ≥90th percentile. Masked hypertension was defined as having normal office BP and abnormal ABPM findings. Urine was analyzed for kidney injury molecule-1, interleukin-18, epidermal growth factor, albumin, and creatinine. The estimated glomerular filtration rate (eGFR) was calculated using the bedside chronic kidney disease in children equation. Recent kidney ultrasound examinations and echocardiograms were reviewed for contralateral kidney size and left ventricular hypertrophy, respectively. Clinical follow-up data were collected for approximately 2 years after study enrollment.
resultsThirty-two participants (median age, 13.6 years [IQR, 10.5-16.3 years]; 75% stage 3 or higher WT) were evaluated at a median of 8.7 years (IQR, 6.5-10.8 years) after therapy; 29 participants underwent unilateral radical nephrectomy, 2 bilateral partial nephrectomy, and 1 radical and contralateral partial nephrectomy. In this cohort, 72% received kidney radiotherapy and 75% received doxorubicin. Recent median eGFR was 95.6 mL/min/1.73 m
conclusionsIn survivors of WT, adverse kidney outcomes were common and should be closely monitored.
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Registered trials
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