Evidence map›Paper›PMID 33290724›Full record

ArticleJournal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons2021

Elevated White Blood Cell Count Resultant Atherogenesis is Associated With Panoramic-Imaged Carotid Plaque.

Tina I Chang, Xiuju Wu, Kristina I Boström, Hoang-Anh Tran, Paulo H Couto-Souza, Arthur H Friedlander

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Tina I ChangDirector, Inpatient Oral and Maxillofacial Surgery at the Veterans Affairs Great Los Angeles Healthcare System and an Instructor in Oral and Maxillofacial Surgery, School of Dentistry, University of California, Los Angeles, CA.
Xiuju WuProject Scientist, Division of Cardiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA.
Kristina I BoströmChief of Cardiology, VA Greater Los Angeles Healthcare System and Professor of Medicine/Cardiology, David Geffen School of Medicine at UCLA and at the Molecular Biology Institute, University of California, Los Angeles, CA.
Hoang-Anh TranPeriodontology Resident, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA.
Paulo H Couto-SouzaProfessor, Maxillofacial Radiology, Graduate Program in Dentistry/School of Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil.
Arthur H FriedlanderAssociate Chief of Staff and Director ofGraduate Medical Education, Veterans Affairs Greater Los Angeles Healthcare System, and Director of, Quality Assurance Hospital Dental Service, Ronald Reagan UCLA Medical Center and Professor-in-Residence of Oral and Maxillofacial Surgery, School of Dentistry, University of California, Los Angeles, CA. Electronic address: arthur.friedlander@va.gov.
University of California, Los Angeles · USVA Greater Los Angeles Healthcare System · USPontifícia Universidade Católica do Paraná · BRRonald Reagan UCLA Medical Center · US

Funding

ULTRASTRUCTURE OF THE INTIMA IN EARLY LESION FORMATIONP01HL030568 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOGELMAN, ALAN M · 1985 to 2019
$55.2M
NHLBI NIH HHS P01 HL030568
6 · The paper itself

Abstract

purposeAtherosclerotic plaques develop as a result of a low-grade, chronic, systemic inflammatory response to the injury of endothelial cells arising from lipid deposition within the intima. Increased white blood cell count (WBCC) is both a validated "biologic marker" of the extent of this inflammatory process and a key participant in the development of subsequent atherosclerotic ischemic heart disease manifesting as myocardial infarction. We sought to determine if calcified carotid artery plaque (CCAP) on a panoramic image (PI), also a validated risk indicator of future myocardial infarction, is associated with increased WBCC. PATIENTS AND

methodsWe retrospectively evaluated the PI and medical records of White male military veterans aged 55 years and older treated by a VA dental service. Established were 2 cohorts of patients, 50 having plaques (CCAP+) and 50 without plaques (CCAP-). Predictor variable was CCAP+; outcome variable was WBCC. Bootstrapping analysis determined the differences in mean WBCCs between groups. Statistical significance set at ≤ 0.05.

resultsThe study group, (mean age 74; range 59 to 91 years) demonstrated a mean WBCC of 8,062 per mm

conclusionsThe presence of CCAP demonstrated on PIs of older Caucasian men is associated with elevated WBCC. Concomitant presence of CCAP on PI and increased WBCC (≥7,800 per mm

Indexed as

AtherosclerosisCarotid Artery DiseasesPlaque, AtheroscleroticAgedAged, 80 and overEndothelial CellsHumansLeukocyte CountMaleMiddle AgedRadiography, PanoramicRetrospective StudiesRisk Factors

Identifiers

PMID33290724
PMCPMC12915551
OpenAlexW3098603932

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.