ReviewCurrent biology : CB2020
Anterior Cingulate Cortex and the Control of Dynamic Behavior in Primates.
Review in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 5 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- The shared neural substrates of emotional mimicry and emotional contagion: an activation likelihood estimation meta-analysis and meta-analytic connectivity modeling analysis.Social cognitive and affective neuroscience · 2025Pooled it
- Functional brain changes in vascular cognitive impairment: a whole brain ALE meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- Neural Effects of Cognitive Behavioral Therapy in Psychiatric Disorders: A Systematic Review and Activation Likelihood Estimation Meta-Analysis.Frontiers in psychology · 2022Pooled it
- Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic review.Frontiers in human neuroscience · 2022Pooled it
- Convergent Functional Changes of Default Mode Network in Mild Cognitive Impairment Using Activation Likelihood Estimation.Frontiers in aging neuroscience · 2021Pooled it
- Receptor architecture shapes the regional organization of the macaque cingulate cortex.Brain structure & function · 2026Article
- Human claustrum neurons encode uncertainty and prediction errors during aversive learning.Nature neuroscience · 2026Article
- Neurobehavioral differences in value-based decision making between people with cocaine use disorder and controls.Experimental and clinical psychopharmacology · 2026Article
- Anterior Cingulate Cortex Projections to the Amygdala in Primates: Topographic and Layer-Specific Organization Underlying Emotion and Mood Regulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Kidney function and brain health: cognitive and structural signatures across cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Interpretable abstractions of artificial neural networks predict behavior and neural activity during human information gathering.Nature neuroscience · 2026Article
- Natural auditory behaviors invoke cognitive brain networks.Current opinion in neurobiology · 2026Review
- Compressive learning scaffolds higher-order network structure to enhance human knowledge acquisition.Nature communications · 2026Article
- Anterior Cingulate Cortex Mediates State-Dependent Prioritization of Distressed Conspecifics.Brain sciences · 2026Article
- A pathway from the anterior cingulate cortex to the lateral habenula controls chronic pain-induced depression in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The anterior cingulate cortex modulates pupil-linked arousal.Science advances · 2026Article
- Anterior cingulate neurons combine outcome monitoring of past decisions with ongoing movement signals.Nature communications · 2026Article
- Human claustrum neurons encode uncertainty and prediction errors during aversive learning.bioRxiv : the preprint server for biology · 2026Article
- Morphometric Similarity Loss and Gray Matter Atrophy Align with Neurotransmitter and Mitochondrial Maps in Drug-Resistant Epilepsy.Neuropsychiatric disease and treatment · 2026Article
- Inflammatory mechanisms underlying early Alzheimer's disease pathology: evidence from the aging rhesus macaque brain.Frontiers in cellular neuroscience · 2026Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The brain mechanism for controlling continuous behavior in dynamic contexts must mediate action selection and learning across many timescales, responding differentially to the level of environmental uncertainty and volatility. In this review, we argue that a part of the frontal cortex known as the anterior cingulate cortex (ACC) is particularly well suited for this function. First, the ACC is interconnected with prefrontal, parietal, and subcortical regions involved in valuation and action selection. Second, the ACC integrates diverse, behaviorally relevant information across multiple timescales, producing output signals that temporally encapsulate decision and learning processes and encode high-dimensional information about the value and uncertainty of future outcomes and subsequent behaviors. Third, the ACC signals behaviorally relevant information flexibly, displaying the capacity to represent information about current and future states in a valence-, context-, task- and action-specific manner. Fourth, the ACC dynamically controls instrumental- and non-instrumental information seeking behaviors to resolve uncertainty about future outcomes. We review electrophysiological and circuit disruption studies in primates to develop this point, discuss its relationship to novel therapeutics for neuropsychiatric disorders in humans, and conclude by relating ongoing research in primates to studies of medial frontal cortical regions in rodents.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.