Evidence map›Paper›PMID 33290688›Full record

SynthesisThe American journal of cardiology2021

Meta-analysis of the Usefulness of Catheter Ablation of Atrial Fibrillation in Patients With Heart Failure With Preserved Ejection Fraction.

Omar M Aldaas, Florentino Lupercio, Douglas Darden, Praneet S Mylavarapu, Chaitanya L Malladi, Frederick T Han, Kurt S Hoffmayer, David Krummen, Gordon Ho, Farshad Raissi and 3 more

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Observational
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. 2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Omar M AldaasSection of Cardiac Electrophysiology, Division of Cardiology, University of California San Diego Health System, La Jolla, California.
Florentino LupercioSection of Cardiac Electrophysiology, Division of Cardiology, University of California San Diego Health System, La Jolla, California.
Douglas DardenSection of Cardiac Electrophysiology, Division of Cardiology, University of California San Diego Health System, La Jolla, California.
Praneet S MylavarapuSection of Cardiac Electrophysiology, Division of Cardiology, University of California San Diego Health System, La Jolla, California.
Chaitanya L MalladiSection of Cardiac Electrophysiology, Division of Cardiology, University of California San Diego Health System, La Jolla, California.
Frederick T HanSection of Cardiac Electrophysiology, Division of Cardiology, University of California San Diego Health System, La Jolla, California.
Kurt S HoffmayerSection of Cardiac Electrophysiology, Division of Cardiology, University of California San Diego Health System, La Jolla, California.
David KrummenSection of Cardiac Electrophysiology, Division of Cardiology, University of California San Diego Health System, La Jolla, California.
Gordon HoSection of Cardiac Electrophysiology, Division of Cardiology, University of California San Diego Health System, La Jolla, California.
Farshad RaissiSection of Cardiac Electrophysiology, Division of Cardiology, University of California San Diego Health System, La Jolla, California.
Ulrika Birgersdotter-GreenSection of Cardiac Electrophysiology, Division of Cardiology, University of California San Diego Health System, La Jolla, California.
Gregory K FeldSection of Cardiac Electrophysiology, Division of Cardiology, University of California San Diego Health System, La Jolla, California.
Jonathan C HsuSection of Cardiac Electrophysiology, Division of Cardiology, University of California San Diego Health System, La Jolla, California. Electronic address: jonathan.hsu@ucsd.edu.
UC San Diego Health System · US

Funding

UC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4M
American Heart Association-American Stroke Association 19CDA34760021NCATS NIH HHS KL2 TR001444
6 · The paper itself

Abstract

Catheter ablation improves clinical outcomes in atrial fibrillation (AF) patients with heart failure (HF) with reduced ejection fraction (HFrEF). However, the role of catheter ablation in HF with a preserved ejection fraction (HFpEF) is less clear. We performed a literature search and systematic review of studies that compared AF recurrence at one year after catheter ablation of AF in patients with HFpEF versus those with HFrEF. Risk ratio (RR; where a RR <1.0 favors the HFpEF group) and mean difference (MD; where MD <0 favors the HFpEF group) 95% confidence intervals (CI) were measured for dichotomous and continuous variables, respectively. Six studies with a total of 1,505 patients were included, of which 764 (51%) had HFpEF and 741 (49%) had HFrEF. Patients with HFpEF experienced similar recurrence of AF 1 year after ablation on or off antiarrhythmic drugs compared with those with HFrEF (RR 1.01; 95% CI 0.76, 1.35). Fluoroscopy time was significantly shorter in the HFpEF group (MD -5.42; 95% CI -8.51, -2.34), but there was no significant difference in procedure time (MD 1.74; 95% CI -11.89, 15.37) or periprocedural adverse events between groups (RR 0.84; 95% CI 0.54,1.32). There was no significant difference in hospitalizations between groups (MD 1.18; 95% CI 0.90, 1.55), but HFpEF patients experienced significantly less mortality (MD 0.41; 95% CI 0.18, 0.94). In conclusion, based on the results of this meta-analysis, catheter ablation of AF in patients with HFpEF appears as safe and efficacious in maintaining sinus rhythm as in those with HFrEF.

Indexed as

Catheter AblationStroke VolumeAtrial FibrillationHeart FailureHospitalizationHumansMortalityOperative TimePostoperative ComplicationsRecurrenceTreatment Outcome

Identifiers

PMID33290688
PMCPMC7902199
OpenAlexW3112455340

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.