ArticleChronic obstructive pulmonary diseases (Miami, Fla.)2021
Progression of Emphysema and Small Airways Disease in Cigarette Smokers.
Article in Chronic obstructive pulmonary diseases (Miami, Fla.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Definitions of early COPD and predictors for disease progression: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Pooled it
- Spirometry parameters used to define small airways obstruction in population-based studies: systematic review.Respiratory research · 2022Pooled it
- Dual-respiratory-phase low-dose quantitative CT for assessing COPD severity.Radiologie (Heidelberg, Germany) · 2026Article
- Cooperation, Defection, and Collapse: A Multiscale Game Theory Framework for Emphysema Progression.Cells · 2026Review
- Yu-Ping-Feng-San mitigates development of emphysema and its exacerbation induced by influenza virus in mice.Chinese herbal medicines · 2026Article
- Time-Frequency Respiratory Impedance Maps Enable Within-Breath Deep Learning for Small Airway Dysfunction Identification.Bioengineering (Basel, Switzerland) · 2026Article
- Longitudinal parametric response mapping on CT in assessing functional small airway disease and emphysema in COPD.Scientific reports · 2025Article
- Mechanically Affected Lung and Progression of Emphysema.American journal of respiratory and critical care medicine · 2025Article
- Leveraging Subjective Parameters and Biomarkers in Machine Learning Models: The Feasibility ofDiagnostics (Basel, Switzerland) · 2025Article
- Computed Tomography Radiomics Features Predict Change in Lung Density and Rate of Emphysema Progression.Annals of the American Thoracic Society · 2025Article
- Expiratory flow limitation development index (ELDI): a novel method of assessing respiratory mechanics in COPD.Respiratory research · 2024Article
- Vessel and Airway Characteristics in One-Year Computed Tomography-defined Rapid Emphysema Progression: SPIROMICS.Annals of the American Thoracic Society · 2024Article
- Late malfunction of subcutaneous implantable cardioverter-defibrillator in a patient with advanced emphysema.HeartRhythm case reports · 2024Article
- Topologic Parametric Response Mapping Identifies Tissue Subtypes Associated with Emphysema Progression.Academic radiology · 2024Article
- Tobacco smoking is associated with combined pulmonary fibrosis and emphysema and worse outcomes in interstitial lung disease.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Analysis of influencing factors and a predictive model of small airway dysfunction in adults.BMC pulmonary medicine · 2023Article
- Emphysema Detection in the Course of Lung Cancer Screening: Optimizing a Rare Opportunity to Impact Population Health.Annals of the American Thoracic Society · 2023Article
- Treatment Trials in Young Patients with Chronic Obstructive Pulmonary Disease and Pre-Chronic Obstructive Pulmonary Disease Patients: Time to Move Forward.American journal of respiratory and critical care medicine · 2022Review
- CD19 and POU2AF1 are Potential Immune-Related Biomarkers Involved in the Emphysema of COPD: On Multiple Microarray Analysis.Journal of inflammation research · 2022Article
Corrections and comments
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Authors and funding
19 authors at 9 institutions in 2 countries.
Funding
Abstract
backgroundLittle is known about factors associated with emphysema progression in cigarette smokers. We evaluated factors associated with change in emphysema and forced expiratory volume in 1 second (FEV
methodsThis retrospective study included individuals participating in the COPD Genetic Epidemiology study who completed the 5-year follow-up, including inspiratory and expiratory computed tomography (CT) and spirometry. All paired CT scans were analyzed using micro-mapping, which classifies individual voxels as emphysema or functional small airway disease (fSAD). Presence and progression of emphysema and FEV
resultsA total of 3088 participants were included with a mean ± SD age of 60.7±8.9 years, including 72 nonsmokers. In all Global initiative for chronic Obstructive Lung Disease (GOLD) stages, the presence of emphysema at baseline was associated with emphysema progression (odds ratio [OR]: GOLD 0: 4.32; preserved ratio-impaired spirometry [PRISm]; 5.73; GOLD 1: 5.16; GOLD 2: 5.69; GOLD 3/4: 5.55; all
conclusionsThe presence of emphysema is an important predictor of emphysema progression. In patients without emphysema, fSAD is associated with the development of emphysema. In participants without spirometric COPD, emphysema progression occurred independently of FEV
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.