Evidence map›Paper›PMID 33290624›Full record

ArticleArthritis care & research2022

Increased Rates of Obstetric Complications Prior to Systemic Sclerosis Diagnosis.

Melody P Chung, Kathleen D Kolstad, Makdine Dontsi, Debbie Postlethwaite, Poonam Manwani, Hongyu Zhao, Sumana Kesh, Julia F Simard, Lorinda Chung

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis care & research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Melody P ChungKaiser Permanente Santa Clara, Santa Clara, California, and Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0003-0221-4910
Kathleen D KolstadStanford University School of Medicine, Stanford, California, USA.
Makdine DontsiKaiser Permanente Northern California, Oakland, California, USA.
Debbie PostlethwaiteKaiser Permanente Northern California, Oakland, California, USA.
Poonam ManwaniKaiser Permanente Santa Clara, Santa Clara, California, USA.
Hongyu ZhaoKaiser Permanente Santa Clara, Santa Clara, California, USA.
Sumana KeshKaiser Permanente Santa Clara, Santa Clara, California, USA.
Julia F SimardStanford University School of Medicine, Stanford, California, USA.ORCID 0000-0001-5735-9856
Lorinda ChungStanford University School of Medicine, Stanford, California, and VA Palo Alto Health Care System, Palo Alto, California, USA.
Kaiser Permanente · USKaiser Permanente Santa Clara Medical Center · USStanford University · USVA Palo Alto Health Care System · US

Funding

Training Program in Adult and Pediatric RheumatologyT32AR050942 · NIAMS · STANFORD UNIVERSITY · PI LEWIS, DAVID BRAM, ROBINSON, WILLIAM H · 2005 to 2025
$6.6M
NIAMS NIH HHS T32 AR050942
6 · The paper itself

Abstract

objectiveTo investigate whether obstetric complications prior to systemic sclerosis (SSc) diagnosis are more common in SSc patients compared to the general obstetric population.

methodsA case-control study was performed at Kaiser Permanente Northern California to compare prior obstetric complications in adult women who later developed SSc (cases) with women from the general obstetric population who did not develop SSc (controls; matched 10:1 by age and year of delivery) from 2007 to 2016. Exposures included past hypertensive disorders of pregnancy (preeclampsia, eclampsia, gestational hypertension), premature rupture of membranes (PROM), intrauterine growth restriction (IUGR), maternal infections, neonatal intensive care unit (NICU) admission, and preterm birth. Fischer's exact tests were used to compare categorical variables. Conditional logistic regression models estimated the odds ratio (OR), and corresponding 95% confidence intervals (95% CIs) for the outcome SSc.

resultsSeventeen SSc cases and 170 non-SSc controls were identified, with median maternal age at delivery 34 years (range 23-46 years) and median time from delivery to SSc diagnosis 2 years (range 0.2-7.3 years). Women with SSc were more likely to be Hispanic and Black. Prior obstetric complications appeared higher in women with an eventual SSc diagnosis compared to controls (70.6% versus 50%), including hypertensive disorders (17.7% versus 9.4%), PROM (11.8% versus 4.1%), IUGR (5.9% versus 1.8%), maternal infection (29.4% versus 14.1%), NICU admissions (23.5% versus 7.7%), and preterm delivery (29.4% versus 21.8%). Women with SSc had a higher odds of delivering infants requiring NICU admission (OR 4.7 [95% CI 1.2-18.8]).

conclusionWomen who eventually develop SSc had trends toward more complicated pregnancy histories before overt diagnosis.

Indexed as

Pregnancy ComplicationsPremature BirthScleroderma, SystemicAdultCase-Control StudiesFemaleFetal Growth RetardationHumansInfantInfant, NewbornMiddle AgedPregnancyPregnancy OutcomeRetrospective StudiesYoung Adult

Identifiers

PMID33290624
PMCPMC8184883
OpenAlexW3111614423

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.