ArticlePloS one2020
Angiography with optical coherence tomography as a biomarker in multiple sclerosis.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Optical coherence tomography angiography analysis methods: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Optical coherence tomography angiography measurements in multiple sclerosis: a systematic review and meta-analysis.Journal of neuroinflammation · 2023Pooled it
- Microvascular impairments detected by optical coherence tomography angiography in multiple sclerosis patients: A systematic review and meta-analysis.Frontiers in neuroscience · 2022Pooled it
- Quantitative ophthalmic posterior segment optical coherence tomography angiography and neurologic conditions: a review.Frontiers in neurologyPooled it
- Retinal Microvascular Features Assessed by Optical Coherence Tomography Angiography in Attention Deficit Hyperactivity Disorder.Journal of clinical medicine · 2026Article
- Optical Coherence Tomography Angiography-Derived Peripapillary Vessel Density Findings in Multiple Sclerosis.Journal of clinical medicine · 2026Article
- Structural and Microvascular Changes in Demyelinating Optic Neuritis Assessed by OCT and OCTA: A 6-Month Longitudinal Study.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- New Method of Early RRMS Diagnosis Using OCT-Assessed Structural Retinal Data and Explainable Artificial Intelligence.Translational vision science & technology · 2025Article
- Barriers in Healthcare to the Use of Optical Coherence Tomography Angiography in Multiple Sclerosis.Neurology and therapy · 2025Review
- Review
- Assessment of Retinal Vessel Tortuosity Index in Patients with Fabry Disease Using Optical Coherence Tomography Angiography (OCTA).Diagnostics (Basel, Switzerland) · 2023Article
- The Heterogeneous Multiple Sclerosis Lesion: How Can We Assess and Modify a Degenerating Lesion?International journal of molecular sciences · 2023Review
- Identifying Optical Coherence Tomography Markers for Multiple Sclerosis Diagnosis and Management.Diagnostics (Basel, Switzerland) · 2023Article
- Ability of Swept-source OCT and OCT-angiography to detect neuroretinal and vasculature changes in patients with Parkinson disease and essential tremor.Eye (London, England) · 2023Article
- Relationship of Vessel Density to Vessel Length Density in Patients with Treated Fabry Disease.Diagnostics (Basel, Switzerland) · 2023Article
- Multi-modal retinal scanning to measure retinal thickness and peripheral blood vessels in multiple sclerosis.Scientific reports · 2022Article
- Retinal imaging with optical coherence tomography in multiple sclerosis: novel aspects.Wiener medizinische Wochenschrift (1946) · 2022Review
- Microvascular changes in the macular and parafoveal areas of multiple sclerosis patients without optic neuritis.Scientific reports · 2022Article
- Towards standardizing retinal optical coherence tomography angiography: a review.Light, science & applications · 2022Review
- The Value of Optical Coherence Tomography Angiography (OCT-A) in Neurological Diseases.Diagnostics (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate superficial retinal microvascular plexuses detected by optical coherence tomography angiography (OCT-A) in multiple sclerosis (MS) subjects and compare them with healthy controls.
methodsA total of 92 eyes from 92 patients with relapsing-remitting MS and 149 control eyes were included in this prospective observational study. OCT-A imaging was performed using Triton Swept-Source OCT (Topcon Corporation, Japan). The vessel density (VD) percentage in the superficial retinal plexus and optic disc area (6 x 6 mm grid) was measured and compared between groups.
resultsMS patients showed a significant decrease VD in the superior (p = 0.005), nasal (p = 0.029) and inferior (p = 0.040) parafoveal retina compared with healthy subjects. Patients with disease durations of more than 5 years presented lower VD in the superior (p = 0.002), nasal (p = 0.017) and inferior (p = 0.022) parafoveal areas compared with healthy subjects. Patients with past optic neuritis episodes did not show retinal microvasculature alterations, but patients with an EDSS score of less than 3 showed a significant decrease in nasal (p = 0.024) and superior (p = 0.006) perifoveal VD when compared with healthy subjects.
conclusionsMS produces a decrease in retinal vascularization density in the superficial plexus of the parafoveal retina. Alterations in retinal vascularization observed in MS patients are independent of the presence of optic nerve inflammation. OCT-A has the ability to detect subclinical vascular changes and is a potential biomarker for diagnosing the presence and progression of MS.
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Registered trials
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