ArticleAsia-Pacific journal of ophthalmology (Philadelphia, Pa.)2020
Eye Diseases Direct Interest to Complement Pathway and Macrophages as Regulators of Inflammation in COVID-19.
Article in Asia-Pacific journal of ophthalmology (Philadelphia, Pa.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Comorbidity patterns associated with severe COVID-19 outcomes: A cohort study based on the UK Biobank.PloS one · 2025Article
- Adverse COVID-19 outcomes in American Veterans with age-related macular degeneration: a case-control study.BMJ open · 2023Article
- COVID-19: Update on Its Ocular Involvements, and Complications From Its Treatments and Vaccinations.Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) · 2021Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
abstractMany of the risk factors for developing severe coronavirus disease 2019 (COVID-19) are also risk factors for eye diseases such as age-related macular degeneration (AMD). During the past decades, macrophages and the complement pathway (as a part of the innate immune system) have been identified as important contributors to the development of AMD, and we suggest that these mechanisms are of similar importance for the clinical course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Based on the experience with AMD, we discuss how behavioral factors such as diet, smoking and higher body mass index, as well as genetic determinants such as the complement and immune pathway genes may lead to the overactive inflammatory phenotypes seen in some patients with COVID-19, and may in part explain the heterogeneity of disease manifestations and outcomes. Based on this experience, we discuss potential genetic research projects and elaborate on preventive and treatment approaches related to COVID-19.
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Registered trials
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