Evidence map›Paper›PMID 33290262›Full record

ArticleAging2020

The improved anticancer effects of Bortezomib-loaded hollow mesoporous silica nanospheres on lymphoma development.

Jie Shen, Ruihuan Wang, Qing Wang, Minjuan Zhang, Chunyan Liu, Zhenxia Tao, Guohong Su

Open access · greenAbstract read
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jie ShenDepartment of Hematology, Centre Hospital of Cangzhou, Cangzhou, Hebei Province, China.
Ruihuan WangDepartment of Hematology, Centre Hospital of Cangzhou, Cangzhou, Hebei Province, China.
Qing WangDepartment of Hematology, Centre Hospital of Cangzhou, Cangzhou, Hebei Province, China.
Minjuan ZhangDepartment of Hematology, Centre Hospital of Cangzhou, Cangzhou, Hebei Province, China.
Chunyan LiuDepartment of Hematology, Centre Hospital of Cangzhou, Cangzhou, Hebei Province, China.
Zhenxia TaoDepartment of Central Laboratory, Centre Hospital of Cangzhou, Cangzhou, Hebei Province, China.
Guohong SuDepartment of Hematology, Centre Hospital of Cangzhou, Cangzhou, Hebei Province, China.
People's Hospital of Cangzhou · CNCangzhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the first clinical proteasome inhibitor, Bortezomib (BTZ) has been reported to improve the outcome of lymphoma. However, due to the unstable property, low bioavailability, and hydrophobic properties of BTZ, it is needed to develop effective drug delivery systems to deliver BTZ into targeted cells or organs. Here we developed a bortezomib (BTZ)-loaded HMSNs (BTZ@HMSNs) system, which can sustain the release of BTZ in targeted tissues.

Indexed as

NanospheresAnimalsAntineoplastic AgentsApoptosisBortezomibCell Line, TumorCell MovementCell ProliferationDrug CarriersHumansIn Vitro TechniquesJanus Kinase 1LymphomaMiceMice, NudeNF-kappa BAntineoplastic AgentsBortezomibDrug CarriersJAK1 protein, humanJanus Kinase 1KIT protein, humanNF-kappa BProtein Tyrosine Phosphatase, Non-Receptor Type 6Proto-Oncogene Proteins c-kitPTPN6 protein, humanRNA, MessengerSilicon DioxideTP53 protein, humanTumor Suppressor Protein p53bortezomibdrug deliveryhollow mesoporous silica nanosphereslymphomatumor-suppressing effect

Identifiers

PMID33290262
PMCPMC7835069
OpenAlexW3109805000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.