Evidence map›Paper›PMID 33290257›Full record

ArticleAging2020

The 1316T>C missenses mutation in MTHFR contributes to MTHFR deficiency by targeting MTHFR to proteasome degradation.

Xi Liu, Yu Li, Menghan Wang, Xiaojun Wang, Limin Zhang, Tao Peng, Wenping Liang, Zhe Wang, Hong Lu

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xi LiuDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Yu LiThe National Clinical Research Center for Geriatric Disease, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Menghan WangDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Xiaojun WangDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Limin ZhangDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Tao PengDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Wenping LiangThe National Clinical Research Center for Geriatric Disease, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Zhe WangThe National Clinical Research Center for Geriatric Disease, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Hong LuDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
First Affiliated Hospital of Zhengzhou University · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

5,10-methylenetetrahydrofolate reductase (MTHFR) deficiency is a rare hereditary disease characterized by defects in folate and homocysteine metabolism. Individuals with inherited

Indexed as

AdolescentAllelesAtaxiaBaclofenBrainCognitive DysfunctionFemaleFolic AcidHomocystinuriaHumansMagnetic Resonance ImagingMethionineMethylenetetrahydrofolate Reductase (NADPH2)Muscle HypertoniaMuscle Relaxants, CentralMuscle Spasticity5,11-methenyltetrahydrohomofolateBaclofenFolic AcidMethionineMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanMuscle Relaxants, CentralProteasome Endopeptidase ComplexVitamin B 12Vitamin B Complexmolecular mechanismsMTHFR deficiencypathogenic mutationproteasome degradationsingle nucleotide polymophorism

Identifiers

PMID33290257
PMCPMC7834980
OpenAlexW3106765742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.