ArticleDiagnostic and interventional radiology (Ankara, Turkey)2021
MRI quantification techniques in fatty liver: the diagnostic performance of hepatic T1, T2, and stiffness measurements in relation to the proton density fat fraction.
Article in Diagnostic and interventional radiology (Ankara, Turkey), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Liver Fat Quantification and Steatosis Grading in Fatty Liver Disease by Magnetic Resonance Imaging: Systematic Review and Meta-Analysis.Journal of gastroenterology and hepatology · 2025Pooled it
- Simultaneous Water-Specific and Fat-Specific T1 and Fat Fraction Mapping of the Abdomen in Free Breathing Conditions With a Radially Encoded MP2RAGE.NMR in biomedicine · 2026Article
- Diagnosing abdominal neoplasms using a T2 mapping radial turbo spin-echo technique with partial volume correction.European radiology · 2026Article
- Imaging-based fibrosis assessment and risk stratification in MASLD.Frontiers in medicine · 2026Review
- Liver Tissue Mapping in Transfusion-Dependent β-Thalassemia: Reproducibility and Clinical Insights from Multiparametric MRI.Diagnostics (Basel, Switzerland) · 2025Article
- Exploring the associations between features from multi-parametric MR images in Glioblastoma using radiomics.BMC medical imaging · 2025Article
- Rapid liver tissue characterization using simultaneous multi-relaxation-time imaging: a comparative study with conventional magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2025Article
- Influence of fat on hepatic T2 relaxation time estimation: a preliminary investigation.Abdominal radiology (New York) · 2025Article
- Non-invasive liver fibrosis markers are increased in obese individuals with non-alcoholic fatty liver disease and the metabolic syndrome.Scientific reports · 2025Article
- Positive Correlation between Lipin-1 and Lipin-2 Expressions and Hepatic T1 Values in IUGR Rats.Current medical imaging · 2025Article
- Respiratory motion-corrected T1 mapping of the abdomen.Magma (New York, N.Y.) · 2024Article
- Association between quadriceps fat pad edema and patellofemoral osteoarthritis: a quantitative Q-Dixon-based magnetic resonance imaging (MRI) analysis.Quantitative imaging in medicine and surgery · 2024Article
- Liver T1 and T2 mapping in a large cohort of healthy subjects: normal ranges and correlation with age and sex.Magma (New York, N.Y.) · 2024Article
- A short-TR single-echo spin-echo breath-hold method for assessing liver T2.Magma (New York, N.Y.) · 2024Article
- Impact of fat on the apparent T1 value of the liver: assessment by water-only derived T1 mapping.European radiology · 2023Article
- Sex-specific associations in multiparametric 3 T MRI measurements in adult livers.Abdominal radiology (New York) · 2023Article
- How to select the quantitative magnetic resonance technique for subjects with fatty liver: A systematic review.World journal of clinical cases · 2022Article
- Liver T1 relaxation time of the 'normal liver' in healthy Asians: measurement with MOLLI and BThe British journal of radiology · 2022Article
- Quantitative MRI in cardiometabolic disease: From conventional cardiac and liver tissue mapping techniques to multi-parametric approaches.Frontiers in cardiovascular medicine · 2022Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNonalcoholic fatty liver disease (NAFLD) can progress to liver cirrhosis and is predicted to become the most frequent indication for liver transplantation in the near future. Noninvasive assessment of NAFLD is important for diagnosis and patient management. This study aims to prospectively determine the liver stiffness and T1 and T2 values in patients with NAFLD and to compare the diagnostic performance of magnetic resonance elastography (MRE) and mapping techniques in relation to the proton density fat fraction (PDFF).
methodsEighty-three patients with NAFLD and 26 participants with normal livers were imaged with a 1.5 T scanner. PDFF measurements obtained from the multiecho Dixon technique were used to quantify the liver fat. MRE, native T1 mapping (modified Look-Locker inversion recovery [MOLLI] schemes 5(3)3, 3(3)3(3)5, and 3(2)3(2)5 and the B1-corrected variable flip angle [VFA] method), and T2 mapping values were correlated with PDFF. The diagnostic performance of MRE and the mapping techniques were analyzed and compared.
resultsT1 values measured with the MOLLI schemes and the B1-corrected VFA (P < 0.001), and the stiffness values from MRE (P = 0.047) were significantly higher in the NAFLD group. No significant difference was found between the groups in terms of T2 values (P = 0.127). In differentiation of the NAFLD and control groups, the B1-corrected VFA technique had slightly higher accuracy and area under the curve (AUC) than the MOLLI schemes. In the NAFLD group, there was a good correlation between the PDFF, MOLLI 3(3)3(3)5 and 3(2)3(2)5, and VFA T1 measurements (r=0.732; r=0.735; r=0.716, P < 0.001, respectively).
conclusionLiver T1 mapping techniques have the potential to distinguish steatotic from nonsteatotic livers, and T1 values seem to have a strong correlation with the liver fat content.
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