ArticleAmerican journal of respiratory cell and molecular biology2021
Lrp1 Regulation of Pulmonary Function. Follow-Up of Human GWAS in Mice.
Article in American journal of respiratory cell and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Assessing the contribution of rare genetic variants to phenotypes of chronic obstructive pulmonary disease using whole-genome sequence data.Human molecular genetics · 2022Article
- The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs.Pulmonary medicine · 2022Review
- Role of the LRP1-pPyk2-MMP9 pathway in hyperoxia-induced lung injury in neonatal rats.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
- Learning a genome-wide score of human-mouse conservation at the functional genomics level.Nature communications · 2021Article
- The Long and Winding Road from GWAS to Obstructive Lung Disease: Is There a Role for LRP1?American journal of respiratory cell and molecular biology · 2021Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Human genome-wide association studies (GWASs) have identified more than 270 loci associated with pulmonary function; however, follow-up studies to determine causal genes at these loci are few. SNPs in low-density lipoprotein receptor-related protein 1 (LRP1) are associated with human pulmonary function in GWASs. Using murine models, we investigated the effect of genetic disruption of the
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